Publication:
The Change in the Linear Energy Transfer of a Clinical Proton Beam in the Presence of Gold Nanoparticles

Дата
2020
Авторы
Belousov, A. V.
Morozov, V. N.
Krusanov, G. A.
Moiseev, A. N.
Klimanov, V. A.
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Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Аннотация
© 2020, Pleiades Publishing, Inc.Abstract: Gold nanoparticles are promising radiosensitizers for proton radiotherapy. However, the physical mechanisms of gold nanoparticles radiosensitization remain unclear. In the present study, the Geant4 toolkit was used to estimate by the Monte-Carlo simulation the changes (1) in the contribution of primary and secondary particles to the absorbed dose, (2) in the dose-averaged linear energy transfer, and (3) in the relative biological effectiveness of a 150 MeV proton beam caused by the addition of 50 mg/mL of gold nanoparticles to the irradiated water phantom. In the presence of gold nanoparticles no significant changes in the absorbed dose and the Bragg peak position were found, at the same time a redistribution of the contribution of secondary particles to the absorbed dose was recorded. An increase in the contributions from protons (~16%), recoil nuclei (~58%), α-particles (~400%), deuterons (~900%), tritons (~3000%), and photons (~7000%) was observed ~10 mm beyond the Bragg peak. The contribution of the secondary electrons decreased by ~35%. This redistribution led to ~5-fold increase in the dose-averaged linear energy transfer at the distal edge of the Bragg curve; this, in turn, may cause the ~1.4−2.2-fold increase in the relative biological effectiveness within this region. Thus, it is critically important to take into account the presence of gold nanoparticles when dosimetric planning proton radiotherapy in order to avoid unwanted damage to the normal tissues around the tumor.
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The Change in the Linear Energy Transfer of a Clinical Proton Beam in the Presence of Gold Nanoparticles / Belousov, A.V. [et al.] // Biophysics (Russian Federation). - 2020. - 65. - № 4. - P. 541-547. - 10.1134/S0006350920040053
URI
https://www.doi.org/10.1134/S0006350920040053
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85092757530&origin=resultslist
 https://openrepository.mephi.ru/handle/123456789/22469
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