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Clinical outcomes in COVID-19 patients infected with different SARS-CoV-2 variants in Marseille, France

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dc.contributor.authorDao, T. L.
dc.contributor.authorHoang, V. T.
dc.contributor.authorNguyen, N. N.
dc.contributor.authorDelerce, J.
dc.contributor.authorChaudet, H.
dc.contributor.authorLevasseur, A.
dc.contributor.authorLagier, J. C.
dc.contributor.authorRaoult, D.
dc.contributor.authorColson, P.
dc.contributor.authorGautret, P.
dc.date.accessioned2024-11-30T03:47:42Z
dc.date.available2024-11-30T03:47:42Z
dc.date.issued2021
dc.description.abstractObjectives: To compare the clinical and epidemiological aspects associated with different predominant lineages circulating in Marseille from March 2020 to January 2021. Methods: In this single-centre retrospective cohort study, characteristics of patients infected with four different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants were documented from medical files. The outcome was the occurrence of clinical failure, defined as hospitalization (for outpatients), transfer to the intensive care unit (inpatients) and death (all). Results: A total of 254 patients were infected with clade 20A (20AS), 85 with Marseille-1 (M1V), 190 with Marseille-4 (M4V) and 211 with N501Y (N501YV) variants. 20AS presented a bell-shaped epidemiological curve and nearly disappeared around May 2020. M1V reached a very weak peak, then disappeared after six weeks. M4V appeared in July presented an atypical wave form for 7 months. N501YV has only recently appeared. Compared with 20AS, patients infected with M1V were less likely to report dyspnoea (adjusted odds ratio (OR) 0.50, p 0.04), rhinitis (aOR 0.57, p 0.04) and to be hospitalized (aOR 0.22, p 0.002). Patients infected with M4V were more likely to report fever than those with 20AS and M1V (aOR 2.49, p < 0.0001 and aOR 2.30, p 0.007, respectively) and to be hospitalized than those with M1V (aOR 4.81, p 0.003). Patients infected with N501YV reported lower rate of rhinitis (aOR 0.50, p 0.001) and anosmia (aOR 0.57, p 0.02), compared with those infected with 20AS. A lower rate of hospitalization was associated with N501YV infection compared with 20AS and M4V (aOR 0.33, p < 0.0001 and aOR 0.27, p < 0.0001, respectively). Conclusions: The four lineages have presentations that differ from one another, epidemiologically and clinically. This supports SARS-CoV-2 genomic surveillance through next-generation sequencing. © 2021 European Society of Clinical Microbiology and Infectious Diseases
dc.format.extentС. 1516.e1-1516.e6
dc.identifier.citationClinical outcomes in COVID-19 patients infected with different SARS-CoV-2 variants in Marseille, France / Dao, T.L. [et al.] // Clinical Microbiology and Infection. - 2021. - 27. - № 10. - P. 1516.e1-1516.e6. - 10.1016/j.cmi.2021.05.029
dc.identifier.doi10.1016/j.cmi.2021.05.029
dc.identifier.urihttps://www.doi.org/10.1016/j.cmi.2021.05.029
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85108504851&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/25391
dc.relation.ispartofClinical Microbiology and Infection
dc.titleClinical outcomes in COVID-19 patients infected with different SARS-CoV-2 variants in Marseille, France
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue10
oaire.citation.volume27
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