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Bioimaging Tools Based on Polyelectrolyte Microcapsules Encoded with Fluorescent Semiconductor Nanoparticles: Design and Characterization of the Fluorescent Properties

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dc.contributor.authorEfimov, A.
dc.contributor.authorAgapova, O.
dc.contributor.authorAgapov, I.
dc.contributor.authorNifontova, G.
dc.contributor.authorNabiev, I. R.
dc.contributor.authorSukhanova, A.
dc.contributor.authorНифонтова, Галина Олеговна
dc.contributor.authorНабиев, Игорь Руфаилович
dc.contributor.authorСуханова, Алена Владимировна
dc.date.accessioned2024-11-20T09:22:09Z
dc.date.available2024-11-20T09:22:09Z
dc.date.issued2019
dc.description.abstract© 2019, The Author(s). Fluorescent imaging is a widely used technique for detecting and monitoring the distribution, interaction, and transformation processes at molecular, cellular, and tissue level in modern diagnostic and other biomedical applications. Unique photophysical properties of fluorescent semiconductor nanocrystals “quantum dots” (QDs) make them advanced fluorophores for fluorescent labeling of biomolecules or optical encoding of microparticles to be used as bioimaging and theranostic agents in targeted delivery, visualization, diagnostics, and imaging. This paper reports on the results of development of an improved approach to the optical encoding of polyelectrolyte microcapsules with stable, covered with the multifunctional polyethyleneglycol derivatives water-soluble QDs, as well as characterization of the optical properties, morphological and structural properties of the encoded microcapsules. The embedding of QDs into the polymer microcapsule membrane through layer-by-layer deposition on a preliminarily formed polymeric polyelectrolyte shell makes it possible to obtain bright fluorescent particles with an adapted charge and size distribution that are distinctly discernible by flow cytometry as individual homogeneous populations. The fluorescent microcapsules developed can be used in further designing bioimaging and theranostic agents sensitive to various external stimuli along with photoexcitation.
dc.identifier.citationBioimaging Tools Based on Polyelectrolyte Microcapsules Encoded with Fluorescent Semiconductor Nanoparticles: Design and Characterization of the Fluorescent Properties / Efimov, A. [et al.] // Nanoscale Research Letters. - 2019. - 14. - 10.1186/s11671-019-2859-4
dc.identifier.doi10.1186/s11671-019-2859-4
dc.identifier.urihttps://www.doi.org/10.1186/s11671-019-2859-4
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85060314840&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000456268800001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/16478
dc.relation.ispartofNanoscale Research Letters
dc.titleBioimaging Tools Based on Polyelectrolyte Microcapsules Encoded with Fluorescent Semiconductor Nanoparticles: Design and Characterization of the Fluorescent Properties
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume14
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