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Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications

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dc.contributor.authorBubnov, A. A.
dc.contributor.authorBelov, V. S.
dc.contributor.authorKargina, Yu. V.
dc.contributor.authorTikhonowski, G. V.
dc.contributor.authorPopov, A. A.
dc.contributor.authorKharin, A. Yu.
dc.contributor.authorShestakov, M. V.
dc.contributor.authorKlimentov, S. M.
dc.contributor.authorTimoshenko, V. Y.
dc.contributor.authorБелов, Владимир Сергеевич
dc.contributor.authorТихоновский, Глеб Валерьевич
dc.contributor.authorПопов, Антон Александрович
dc.contributor.authorКлиментов, Сергей Михайлович
dc.contributor.authorТимошенко, Виктор Юрьевич
dc.contributor.authorБубнов, Александр Андреевич
dc.date.accessioned2024-12-27T08:52:27Z
dc.date.available2024-12-27T08:52:27Z
dc.date.issued2023
dc.description.abstractThe combination of photothermal and magnetic functionalities in one biocompatible nanoformulation forms an attractive basis for developing multifunctional agents for biomedical theranostics. Here, we report the fabrication of silicon-iron (Si-Fe) composite nanoparticles (NPs) for theranostic applications by using a method of femtosecond laser ablation in acetone from a mixed target combining silicon and iron. The NPs were then transferred to water for subsequent biological use. From structural analyses, it was shown that the formed Si-Fe NPs have a spherical shape and sizes ranging from 5 to 150 nm, with the presence of two characteristic maxima around 20 nm and 90 nm in the size distribution. They are mostly composed of silicon with the presence of a significant iron silicide content and iron oxide inclusions. Our studies also show that the NPs exhibit magnetic properties due to the presence of iron ions in their composition, which makes the formation of contrast in magnetic resonance imaging (MRI) possible, as it is verified by magnetic resonance relaxometry at the proton resonance frequency. In addition, the Si-Fe NPs are characterized by strong optical absorption in the window of relative transparency of bio-tissue (650-950 nm). Benefiting from such absorption, the Si-Fe NPs provide strong photoheating in their aqueous suspensions under continuous wave laser excitation at 808 nm. The NP-induced photoheating is described by a photothermal conversion efficiency of 33-42%, which is approximately 3.0-3.3 times larger than that for pure laser-synthesized Si NPs, and it is explained by the presence of iron silicide in the NP composition. Combining the strong photothermal effect and MRI functionality, the synthesized Si-Fe NPs promise a major advancement of modalities for cancer theranostics, including MRI-guided photothermal therapy and surgery.
dc.identifier.citationLaser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications / Bubnov, A. A. [et al.] // Nanomaterials. - 2023. - 13. - № 15. - 10.3390/nano13152256
dc.identifier.doi10.3390/nano13152256
dc.identifier.urihttps://www.doi.org/10.3390/nano13152256
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85167680257&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:001046319300001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29151
dc.relation.ispartofNanomaterials
dc.subjectMetal Nanoparticles
dc.subjectLaser Ablation
dc.subjectUpconversion Nanoparticles
dc.subjectFemtosecond Laser Writing
dc.subjectNanocomposite Materials
dc.subjectIron oxide nanoparticles
dc.subjectNanomaterials
dc.titleLaser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue15
oaire.citation.volume13
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