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Methylene blue in anticancer photodynamic therapy: systematic review of preclinical studies

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dc.contributor.authorTaldaev, A.
dc.contributor.authorTerekhov, R.
dc.contributor.authorNikitin, I.
dc.contributor.authorMelnik, E.
dc.contributor.authorLoschenov, V.
dc.contributor.authorЛощенов, Виктор Борисович
dc.date.accessioned2024-12-27T10:37:44Z
dc.date.available2024-12-27T10:37:44Z
dc.date.issued2023
dc.description.abstractBackground: Methylene blue has a long history of clinical application. Thanks to phenothiazine chromophore, it has potential in photodynamic anticancer therapy. In spite of the growing body of literature that has evaluated the action of this dye on different types of cancer, the systematic understanding of this problem is still lacking. Therefore, this systematic review was performed to study the efficacy of methylene blue in photodynamic anticancer therapy. Methods: This systematic review was carried out in accordance with the PRISMA guidelines, and the study protocol was registered in PROSPERO (CRD42022368738). Articles for the systematic review were identified through the PubMed database. SYRCLE s risk of bias tool was used to assess the studies. The results of systematic analysis are presented as narrative synthesis. Results: Ten studies met the inclusion criteria and these full texts were reviewed. In the selected articles, the dosage of dye infusion ranged from 0.04 to 24.12 mg/kg. The effectiveness of photodynamic therapy with methylene blue against different types of cancer was confirmed by a decrease in tumor sizes in seven articles. Conclusion: The results of the systematic review support the suggestions that photodynamic therapy with methylene blue helps against different types of cancer, including colorectal tumor, carcinoma, and melanoma. In cases of nanopharmaceutics use, a considerable increase of anticancer therapy effectiveness was observed. The further research into methylene blue in photodynamic anticancer therapy is needed. Systematic Review Registration: (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=368738), identifier (CRD42022368738).
dc.identifier.citationMethylene blue in anticancer photodynamic therapy: systematic review of preclinical studies / Taldaev, A. [et al.] // Frontiers in Pharmacology. - 2023. - 14. - 10.3389/fphar.2023.1264961
dc.identifier.doi10.3389/fphar.2023.1264961
dc.identifier.urihttps://www.doi.org/10.3389/fphar.2023.1264961
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85173814129&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29347
dc.relation.ispartofFrontiers in Pharmacology
dc.subjectMethylene blue
dc.subjectPhotodynamic Therapy
dc.titleMethylene blue in anticancer photodynamic therapy: systematic review of preclinical studies
dc.typeReview
dspace.entity.typePublication
oaire.citation.volume14
relation.isAuthorOfPublication371640a5-5007-444c-a657-ccfac33ccebd
relation.isAuthorOfPublication.latestForDiscovery371640a5-5007-444c-a657-ccfac33ccebd
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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