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Photodynamic action of photosensitizers based on polycationic derivatives of synthetic bacteriochlorin against human lung cancer cells A549

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dc.contributor.authorKogan, E. A.
dc.contributor.authorKarshieva, S. S.
dc.contributor.authorMakarova, E. A.
dc.contributor.authorDalina, A. A.
dc.contributor.authorMeerovich, G. A.
dc.contributor.authorAkhlyustina, E. V.
dc.contributor.authorGonchukov, S. A.
dc.contributor.authorLoschenov, V. B.
dc.contributor.authorМеерович, Геннадий Александрович
dc.contributor.authorАхлюстина, Екатерина Витальевна
dc.contributor.authorГончуков, Сергей Александрович
dc.contributor.authorЛощенов, Виктор Борисович
dc.date.accessioned2024-12-26T09:02:56Z
dc.date.available2024-12-26T09:02:56Z
dc.date.issued2022
dc.description.abstract© 2022 Astro Ltd.In view of their potential in the treatment of oncological diseases, photosensitizers (PS) have been the object of active research for the last years. The applied therapeutic photodynamic method involves the activation of a PS by light at a specific wavelength. PS interacts with oxygen and catalyzes the production of singlet oxygen molecules or radical oxygen species which leads to tumor cell death. This work is devoted to the study of the effectiveness of the photodynamic action of new PSs based on polycationic derivatives of synthetic bacteriochlorin on human lung cancer cells A549. The results obtained show that these PS effectively bind to these cells, have high phototoxicity and low 'dark' cytotoxicity for them. Morphological and immunohistochemical studies show that photodynamic effect leads to induction of cell necrosis and apoptosis, as well as a sharp decrease in mitotic activity.
dc.identifier.citationPhotodynamic action of photosensitizers based on polycationic derivatives of synthetic bacteriochlorin against human lung cancer cells A549 / Kogan, E.A. [et al.] // Laser Physics Letters. - 2022. - 19. - № 3. - 10.1088/1612-202X/ac4e96
dc.identifier.doi10.1088/1612-202X/ac4e96
dc.identifier.urihttps://www.doi.org/10.1088/1612-202X/ac4e96
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85125535338&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000751058100001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/28794
dc.relation.ispartofLaser Physics Letters
dc.titlePhotodynamic action of photosensitizers based on polycationic derivatives of synthetic bacteriochlorin against human lung cancer cells A549
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.volume19
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