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On the possibility of photodynamic inactivation of tracheobronchial tree pathogenic microbiota using methylene blue (in vitro study)

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dc.contributor.authorTiganova, I. G.
dc.contributor.authorZulufova, I. D.
dc.contributor.authorOvchinnikov, R. S.
dc.contributor.authorSolovyev, A. I.
dc.contributor.authorMeerovich, G. A.
dc.contributor.authorAkhlyustina, E. V.
dc.contributor.authorKozlikina, E. I.
dc.contributor.authorNekhoroshev, A. V.
dc.contributor.authorGlechik, D. A.
dc.contributor.authorLoschenov, V. B.
dc.contributor.authorМеерович, Геннадий Александрович
dc.contributor.authorАхлюстина, Екатерина Витальевна
dc.contributor.authorЛощенов, Виктор Борисович
dc.date.accessioned2024-12-26T08:26:14Z
dc.date.available2024-12-26T08:26:14Z
dc.date.issued2022
dc.description.abstract© 2022Background: The treatment of patients after mechanical ventilation of lungs suffering from a multi-species infection of the tracheobronchial tree can be complicated. The situation is aggravated in patients with post-intubation tracheal stenosis, where infection plays a leading pathogenetic role in damage to the tracheal wall. As a result of such a pathological process, cicatricial stenosis of the trachea of purulent-inflammatory infectious genesis or infected tracheal stenosis (ITS) may occur. Methods: In this work, we studied the possibility of photodynamic inactivation of pathogenic microbiota typical for patients with ITS using methylene blue (MB) as a photosensitizer. Results: 13 clinical isolates of 8 species of bacteria from 9 patients were susceptible to photodynamic inactivation with MB. 30 μM of MB at a light irradiation dose of 25 J/cm2 and incubation with MB for 15 min allows to completely inactivate bacteria found in the tracheobronchial secretions of patients with ITS. Conclusions: MB retains its optico-physical properties in the range of 3–30 μM and provides effective inactivation of isolated Gram-positive and Gram-negative bacteria, including multi- and pan-resistant to antibiotics.
dc.identifier.citationOn the possibility of photodynamic inactivation of tracheobronchial tree pathogenic microbiota using methylene blue (in vitro study) / Tiganova, I.G. [et al.] // Photodiagnosis and Photodynamic Therapy. - 2022. - 38. - 10.1016/j.pdpdt.2022.102753
dc.identifier.doi10.1016/j.pdpdt.2022.102753
dc.identifier.urihttps://www.doi.org/10.1016/j.pdpdt.2022.102753
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85124545671&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000767356400008
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/28732
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.titleOn the possibility of photodynamic inactivation of tracheobronchial tree pathogenic microbiota using methylene blue (in vitro study)
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume38
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