Персона: Попов, Антон Александрович
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Антон Александрович
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- ПубликацияТолько метаданныеIn vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles(2019) Bailly, A. -L.; Correard, F.; Tselikov, G.; Chaspoul, F.; Popov, A.; Kabashin, A. V.; Попов, Антон Александрович; Кабашин, Андрей ВикторовичCapable of generating plasmonic and other effects, gold nanostructures can offer a variety of diagnostic and therapy functionalities for biomedical applications, but conventional chemically-synthesized Au nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synthesized Au nanoparticles (AuNP) present a viable alternative to chemical counterparts and can offer exceptional purity (no trace of contaminants) and unusual surface chemistry making possible direct conjugation with biocompatible polymers (dextran, polyethylene glycol). This work presents the first pharmacokinetics, biodistribution and safety study of laser-ablated dextran-coated AuNP (AuNPd) under intravenous administration in small animal model. Our data show that AuNPd are rapidly eliminated from the blood circulation and accumulated preferentially in liver and spleen, without inducing liver or kidney toxicity, as confirmed by the plasmatic ALAT and ASAT activities, and creatininemia values. Despite certain residual accumulation in tissues, we did not detect any sign of histological damage or inflammation in tissues, while IL-6 level confirmed the absence of any chronic inflammation. The safety of AuNPd was confirmed by healthy behavior of animals and the absence of acute and chronic toxicities in liver, spleen and kidneys. Our results demonstrate that laser-synthesized AuNP are safe for biological systems, which promises their successful biomedical applications.
- ПубликацияТолько метаданныеFemtosecond laser-ablative synthesis of plasmonic Au and TiN nanoparticles for biomedical applications(2019) Tselikov, G.; Al-Kattan, A.; Popov, A. A.; Kabashin, A. V.; Попов, Антон Александрович; Кабашин, Андрей ВикторовичCopyright © 2019 SPIE.Methods of femtosecond laser ablation and fragmentation in liquids were used to fabricate bare (ligand-free) plasmonic Au and TiN nanoparticles. By varying laser parameters (laser energy, focusing conditions) and environment (deionized water, acetone), we were able to synthesize spherical Au and TiN nanoparticles of variable size between a few of nm and 30-40 nm under a relatively low size dispersion. EDX and XPS tests confirm that both nanoparticle samples consist of gold and titanium nitride in the absence of any impurity. While Au based nanoparticles demonstrate a standard plasmonic extinction peak in the visible green range (520-540 nm), TiN counterparts exhibit a broad red-shifted peak centered around 650-700 nm even for very small nanoparticle sizes (4-5 nm). We finally discuss possible applications of laser-synthesized Au nanoparticles in SERS, SEIRA and electrocatalysis, while TiN nanoparticles are considered as promising sensitizers of photothermal therapies.
- ПубликацияТолько метаданныеPlasmonic Si Au core-satellite nanoparticles prepared by laser-assisted synthesis for photothermal therapy(2021) Al-Kattan, A.; Tselikov, G.; Popov, A. A.; Kabashin, A. V.; Попов, Антон Александрович; Кабашин, Андрей ВикторовичAbstract We describe a laser-assisted methodology for the fabrication of Si@Au core-satellite nanostructures for photothermal therapy applications. The methodology consists in laser ablative synthesis of Si and Au NPs in water/ethanol solutions, followed by a chemical modification of the Si NPs by APTMS and their subsequent decoration by the Au NPs. We show that despite a relatively small size (< 40 nm) the formed core-satellites exhibit a strong plasmonic absorption peak centred around 610 nm and having a large tail over 700 nm overlapping with the first optical window of relative tissue transparency. Being relatively small and exempt of any toxic impurity due to ultraclean laser synthesis, the fabricated nanoparticles promise a major advancement of imaging and phototherapy modalities based on plasmonic properties of nanomatererials.
- ПубликацияТолько метаданныеLaser ablation-assisted synthesis of plasmonic si@au core-satellite nanocomposites for biomedical applications(2021) Al-Kattan, A.; Tselikov, G.; Metwally, K.; Mensah, S.; Popov, A. A.; Kabashin, A. V.; Попов, Антон Александрович; Кабашин, Андрей Викторович© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Owing to strong plasmonic absorption and excellent biocompatibility, gold nanostruc-tures are among best candidates for photoacoustic bioimaging and photothermal therapy, but such applications require ultrapure Au-based nanoformulations of complex geometry (core-shells, nano-rods) in order to shift the absorption band toward the region of relative tissue transparency (650– 1000 nm). Here, we present a methodology for the fabrication of Si@Au core-satellite nanostruc-tures, comprising of a Si core covered with small Au nanoparticles (NP), based on laser ablative synthesis of Si and Au NPs in water/ethanol solutions, followed by a chemical modification of the Si NPs by 3-aminopropyltrimethoxysilane (APTMS) and their subsequent decoration by the Au NPs. We show that the formed core-satellites have a red-shifted plasmonic absorption feature compared to that of pure Au NPs (520 nm), with the position of the peak depending on APTMS amount, water−ethanol solvent percentage and Si−Au volume ratio. As an example, even relatively small 40-nm core-satellites (34 nm Si core + 4 nm Au shell) provided a much red shifted peak centered around 610 nm and having a large tail over 700 nm. The generation of the plasmonic peak is confirmed by modeling of Si@Au core-shells of relevant parameters via Mie theory. Being relatively small and exempt of any toxic impurity due to ultraclean laser synthesis, the Si@Au core-satellites promise a major advancement of imaging and phototherapy modalities based on plasmonic properties of na-nomaterials.
- ПубликацияТолько метаданныеLaser-Ablative Synthesis of Ultrapure Magneto-Plasmonic Core-Satellite Nanocomposites for Biomedical Applications(2022) Swiatkowska-Warkocka, Z.; Marszalek, M.; Tselikov, G.; Al-Kattan, A.; Popov, A. A.; Zelepukin, I. V.; Deyev, S. M.; Klimentov, S. M.; Kabashin, A. V.; Попов, Антон Александрович; Деев, Сергей Михайлович; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович© 2022 by the authors. Licensee MDPI, Basel, Switzerland.The combination of magnetic and plasmonic properties at the nanoscale promises the development of novel synergetic image-guided therapy strategies for the treatment of cancer and other diseases, but the fabrication of non-contaminated magneto-plasmonic nanocomposites suitable for biological applications is difficult within traditional chemical methods. Here, we describe a methodology based on laser ablation from Fe target in the presence of preliminarily ablated water-dispersed Au nanoparticles (NPs) to synthesize ultrapure bare (ligand-free) core-satellite nanostructures, consisting of large (several tens of nm) Fe-based core decorated by small (mean size 7.5 nm) Au NPs. The presence of the Fe-based core conditions a relatively strong magnetic response of the nanostructures (magnetization of >12.6 emu/g), while the Au NPs-based satellite shell provides a broad extinction peak centered at 550 nm with a long tale in the near-infrared to overlap with the region of relative tissue transparency (650–950 nm). We also discuss possible mechanisms responsible for the formation of the magnetic-plasmonic nanocomposites. We finally demonstrate a protocol to enhance colloidal stability of the core-satellites in biological environment by their coating with different polymers. Exempt of toxic impurities and combining strong magnetic and plasmonic responses, the formed core-satellite nanocomposites can be used in biomedical applications, including photo-and magneto-induced therapies, magnetic resonance imaging or photoacoustic imaging.