Персона:
Попов, Антон Александрович

Научные группы

Научная группа

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

Фамилия

Попов

Имя

Антон Александрович

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Теперь показываю 1 - 10 из 36

Открытый доступ
Localized infrared radiation-induced hyperthermia sensitized by laser-ablated silicon nanoparticles for phototherapy applications
(2020) Oleshchenko, V. A.; Karpukhina, O. V.; Bezotosnyi, V. V.; Kharin, A. Y.; Alykova, A. F.; Karpov, N. V.; Popov, A. A.; Klimentov, S. M.; Zavestovskaya, I. N.; Kabashin, A. V.; Timoshenko, V. Y.; Попов, Антон Александрович; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Кабашин, Андрей Викторович; Тимошенко, Виктор Юрьевич
© 2020 Elsevier B.V.Silicon (Si) nanoparticles (NPs) synthesized by methods of laser ablation in water are explored as sensitizers of photothermal therapy under a laser excitation in the window of relative tissue transparency. Based on theoretical calculations and experimental data, it is shown that the NPs can be heated up to temperatures above 42–50 °C by laser diode irradiation at 808 nm in continuous wave (CW) and quasi-continuous wave (QCW) regimes. Profiting from the laser-induced heating, a high efficiency Si-NPs as sensitizers of the hyperthermia of cells in Paramecium Caudatum model is demonstrated. The QCW regime is found to be more efficient, leading to complete cell destruction even under relatively mild laser irradiation conditions. The obtained data evidence a great potential in using laser-ablated Si-NPs as sensitizers of photohyperthermia in antibacterial or cancer therapy applications.
Только метаданные
Laser-synthesized plasmonic HfN-based nanoparticles as a novel multifunctional agent for photothermal therapy
(2024) Pastukhov, A. I.; Savinov, M. S.; Zelepukin, I. V.; Babkova, J. S.; Tikhonowski, G. V.; Popov, A. A.; Klimentov, S. M.; Zavestovskaya, I. N.; Deyev, S. M.; Kabashin, A. V.; Савинов, Максим Сергеевич; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Деев, Сергей Михайлович; Кабашин, Андрей Викторович
HfN nanoparticles exhibiting a tunable plasmonic feature in the near-IR were synthesized by laser ablation in liquids. A strong photothermal therapeutic effect yielding 100% cells death under 808 nm irradiation of nanoparticles was reported.
Только метаданные
Bismuth nanoparticles-enhanced proton therapy: Concept and biological assessment
(2024) Zavestovskaya, I. N.; Tikhonowski, G. V.; Savinov, M.; Shakhov, P. V.; Popov, A. A.; Klimentov, S. M.; Deyev, S. M.; Завестовская, Ирина Николаевна; Тихоновский, Глеб Валерьевич; Савинов, Максим Сергеевич; Шахов, Павел Владимирович; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович
Только метаданные
Laser-synthesized TiN-based nanoparticles as novel efficient electrostatic nanosorbent for environmental water cleaning
(2024) Syuy, A. V.; Martynov, I. V.; Zavidovskiy, I. A.; Tikhonowski, G. V.; Tselikov, D. I.; Savinov, M. S.; Sozaev, I. V.; Popov, A. A.; Klimentov, S. M.; Тихоновский, Глеб Валерьевич; Целиков, Даниил Игоревич; Савинов, Максим Сергеевич; Созаев, Ислам Владимирович; Попов, Антон Александрович; Климентов, Сергей Михайлович
Только метаданные
Ultrafast laser ablation of gold in liquids: Effect of laser pulse overlap-induced surface porosity on size distribution of formed nanoparticles
(2024) Ivanov, D. S.; Shakhov, P.; Tikhonowsky, G.; Popov, A. A.; Mayorov, A. N.; Zavestovskaya, I. N.; Klimentov, S. M.; Шахов, Павел Владимирович; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Майоров, Алексей Николаевич; Завестовская, Ирина Николаевна; Климентов, Сергей Михайлович
Только метаданные
Effect of Oxygen on Colloidal Stability of Titanium Nitride Nanoparticles Synthesized by Laser Ablation in Liquids
(2021) Tikhonowski, G. V.; Popova-Kuznetsova, E. A.; Aleshchenko, Y. A.; Klimentov, S. M.; Kabashin, A. V.; Popov, A. A.; Тихоновский, Глеб Валерьевич; Попова-Кузнецова, Елена Алефтиновна; Алещенко, Юрий Анатольевич; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович; Попов, Антон Александрович
© 2021, Allerton Press, Inc.Abstract: The effect of oxygen existing in an ablation medium during synthesis of titanium nitride (TiN) nanoparticles (NPs) by pulsed laser ablation in liquid (PLAL) on colloidal stability of obtained solutions was studied. It was shown that an increase in the oxygen content both incorporated in liquid molecules and in the form of dissolved gas increases the colloidal stability of synthesized NPs. The results obtained extend the range of available methods for developing new nanomaterials due to control of colloidal stability of laser-synthesized NPs.
Только метаданные
Cytotoxicity of Laser-Synthesized Nanoparticles of Elemental Bismuth
(2024) Shakhov, P. V.; Tikhonowski, G. V.; Popov, A. A.; Iliasov, A. R.; Lebedev, A. A.; Klimentov, S. M.; Шахов, Павел Владимирович; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Илясов, Артём Романович; Лебедев, Анатолий Алексеевич; Климентов, Сергей Михайлович
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Laser-Ablative Engineering of ZrN-Based Nanoparticles for Photothermal Therapy and SERS-Based Biological Imaging
(2024) Pastukhov, A. I.; Babkova, J. S.; Zelepukin, I. V.; Popov, A. A.; Klimentov, S. M.; Prasad, P. N.; Deyev, S. M.; Бабкова, Юлия Сергеевна; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович
Только метаданные
Boron Nanoparticle-Enhanced Proton Therapy: Molecular Mechanisms of Tumor Cell Sensitization
(2024) Popov, A. L.; Kolmanovich, D. D.; Chukavin, N. N.; Zelepukin, I. V.; Tikhonowski, G. V.; Popov, A. A.; Klimentov, S. M.; Deyev, S. M.; Zavestovskaya, I. N.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович; Завестовская, Ирина Николаевна
Boron-enhanced proton therapy has recently appeared as a promising approach to increase the efficiency of proton therapy on tumor cells, and this modality can further be improved by the use of boron nanoparticles (B NPs) as local sensitizers to achieve enhanced and targeted therapeutic outcomes. However, the mechanisms of tumor cell elimination under boron-enhanced proton therapy still require clarification. Here, we explore possible molecular mechanisms responsible for the enhancement of therapeutic outcomes under boron NP-enhanced proton therapy. Spherical B NPs with a mode size of 25 nm were prepared by methods of pulsed laser ablation in water, followed by their coating by polyethylene glycol to improve their colloidal stability in buffers. Then, we assessed the efficiency of B NPs as sensitizers of cancer cell killing under irradiation with a 160.5 MeV proton beam. Our experiments showed that the combined effect of B NPs and proton irradiation induces an increased level of superoxide anion radical generation, which leads to the depolarization of mitochondria, a drop in their membrane mitochondrial potential, and the development of apoptosis. A comprehensive gene expression analysis (via RT-PCR) confirmed increased overexpression of 52 genes (out of 87 studied) involved in the cell redox status and oxidative stress, compared to 12 genes in the cells irradiated without B NPs. Other possible mechanisms responsible for the B NPs-induced radiosensitizing effect, including one related to the generation of alpha particles, are discussed. The obtained results give a better insight into the processes involved in the boron-induced enhancement of proton therapy and enable one to optimize parameters of proton therapy in order to maximize therapeutic outcomes.
Открытый доступ
Laser-ablative synthesis of stable aqueous solutions of elemental bismuth nanoparticles for multimodal theranostic applications
(2020) Bulmahn, J. C.; Kuzmin, A.; Tikhonowski, G.; Popov, A. A.; Klimentov, S. M.; Kabashin, A. V.; Prasad, P. N.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.Elemental bismuth (Bi) nanoparticles (NPs), with the high atomic density of the Bi nuclei, could serve as efficient targeted agents for cancer treatment, with applications such as contrast agents for computed tomography (CT) imaging, sensitizers for image-guided X-ray radiotherapy, and photothermal therapy. However, the synthesis of elemental Bi NPs suitable for biological applications is difficult using conventional chemical routes. Here, we explore the fabrication of ultrapure Bi-based nanomaterials by femtosecond laser ablation from a solid Bi target in ambient liquids and characterize them by a variety of techniques, including TEM, SEM, XRD, FTIR, Raman, and optical spectroscopy. We found that laser-ablative synthesis using an elemental Bi solid target leads to the formation of spherical Bi NPs having the mean size of 20–50 nm and a low size-dispersion. The NPs prepared in water experience a fast (within a few minutes) conversion into 400–500 nm flake-like nanosheets, composed of bismuth subcarbonates, (BiO)2 CO3 and (BiO)4 CO3 (OH)2, while the NPs prepared in acetone demonstrate high elemental stability. We introduce a procedure to obtain a stable aqueous solution of elemental Bi NPs suitable for biological applications, based on the coating of Bi NPs prepared in acetone with Pluronic® F68 and their subsequent transfer to water. We also show that the laser-synthesized elemental Bi NPs, due to their vanishing band gap, exhibit remarkable absorption in the infrared range, which can be used for the activation of photothermal therapy in the near IR-to-IR window with maximum optical transparency in biological media. Exempt of any toxic synthetic by-products, laser-ablated elemental Bi NPs present a novel appealing nanoplatform for combination image-guided photoradiotherapies.