Персона: Кабашин, Андрей Викторович
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Организационные подразделения
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Руководитель научной группы "Лаборатория «Бионанофотоники"
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Кабашин
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Андрей Викторович
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- ПубликацияТолько метаданныеLaser-ablative synthesis of aggregation-induced enhanced emission luminophore dyes in aqueous solutions(2019) Lim, C. -K.; Popov, A. A.; Tselikov, G.; Heo, J.; Kabashin, A. V.; Prasad, P. N.; Кабашин, Андрей ВикторовичCopyright © 2019 SPIE.Methods of femtosecond laser ablation in deionized water were used to fabricate ultrasmall (< 2 nm), bare (ligand-free) organic luminophore DCEtDCS nanoparticles, which exhibit aggregation enhanced emission in the green range (533 nm) with the quantum yield exceeding 58% and provide no concentration quenching. In contrast to chemically synthesized counterparts, laser-synthesized DCEtDCS nanoparticles do not contain any organic impurities due to their preparation in aqueous medium and do not require surfactants to stabilize colloidal solutions, which makes them highly suitable for intracellular uptake and bioimaging. The highly negative surface charge of these nanoparticles impeded their cellular uptake, but when the surface was coated with chitosan, a cationic polymer, intracellular uptake in microglia was achieved. Using in vitro model, we finally demonstrate the efficient employment of ultrasmall and surfactant free fluorescent organic nanoparticles prepared by laser ablation as markers in bioimaging.
- ПубликацияТолько метаданныеFemtosecond laser-ablative synthesis of plasmonic Au and TiN nanoparticles for biomedical applications(2019) Tselikov, G.; Al-Kattan, A.; Popov, A. A.; Kabashin, A. V.; Попов, Антон Александрович; Кабашин, Андрей ВикторовичCopyright © 2019 SPIE.Methods of femtosecond laser ablation and fragmentation in liquids were used to fabricate bare (ligand-free) plasmonic Au and TiN nanoparticles. By varying laser parameters (laser energy, focusing conditions) and environment (deionized water, acetone), we were able to synthesize spherical Au and TiN nanoparticles of variable size between a few of nm and 30-40 nm under a relatively low size dispersion. EDX and XPS tests confirm that both nanoparticle samples consist of gold and titanium nitride in the absence of any impurity. While Au based nanoparticles demonstrate a standard plasmonic extinction peak in the visible green range (520-540 nm), TiN counterparts exhibit a broad red-shifted peak centered around 650-700 nm even for very small nanoparticle sizes (4-5 nm). We finally discuss possible applications of laser-synthesized Au nanoparticles in SERS, SEIRA and electrocatalysis, while TiN nanoparticles are considered as promising sensitizers of photothermal therapies.