Персона: Кабашин, Андрей Викторович
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Руководитель научной группы "Лаборатория «Бионанофотоники"
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Кабашин
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Андрей Викторович
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- ПубликацияТолько метаданныеColloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine(2020) Duflot, V. R.; Popova-Kuznetsova, E.; Tikhonowski, G.; Popov, A. A.; Deyev, S. M.; Klimentov, S. M.; Zavestovskaya, I. N.; Prasad, P. N.; Kabashin, A. V.; Попова-Кузнецова, Елена Алефтиновна; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Деев, Сергей Михайлович; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Кабашин, Андрей Викторович© 2020 SPIE.Nanotechnology promises a major improvement of efficacy of nuclear medicine by targeted delivery of radioactive agents to tumors, but this approach still needs novel efficient nanoformulations to maximize diagnostic and therapeutic functions. Here, we present a two-step method of laser ablation and fragmentation in water to produce non-radioactive 152Sm-enriched samarium oxide nanoparticles (Sm NPs), which can be converted to radioactive form of 153Sm beta-emitters by neutron capture reaction. We found that laser ablation in deionized water leads to the formation of NPs having diverse morphology and broad size dispersion. To improve size characteristics of formed NPs, we applied additional femtosecond laser fragmentation step, which made possible a good control of mean NPs size under a drastic narrowing of size dispersion, and the spherical shape of formed NPs. Obtained colloidal solutions of Sm NPs were stable for several weeks after the synthesis. The formed NPs present a very promising object for nuclear nanomedicine.
- ПубликацияТолько метаданныеBi-Modal Nonlinear Optical Contrast from Si Nanoparticles for Cancer Theranostics(2019) Rogov, A.; Ryabchikov, Y. V.; Geloen, A.; Tishchenko, I.; Kharin, A. Y.; Lysenko, V.; Zavestovskaya, I. N.; Kabashin, A. V.; Timoshenko, V. Y.; Завестовская, Ирина Николаевна; Кабашин, Андрей Викторович; Тимошенко, Виктор Юрьевич© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Presenting a safe alternative to conventional compound quantum dots and other functional nanostructures, nanosilicon can offer a series of breakthrough hyperthermia-based therapies under near-infrared, radiofrequency, ultrasound, etc., excitation, but the size range to sensitize these therapies is typically too large (>10 nm) to enable efficient imaging functionality based on photoluminescence properties of quantum-confined excitonic states. Here, it is shown that large Si nanoparticles (NPs) are capable of providing two-photon excited luminescence (TPEL) and second harmonic generation (SHG) responses, much exceeding that of smaller Si NPs, which promises their use as probes for bi-modal nonlinear optical bioimaging. It is finally demonstrated that the combination of TPEL and SHG channels makes possible efficient tracing of both separated Si NPs and their aggregations in different cell compartments, while the resolution of such an approach is enough to obtain 3D images. The obtained bi-modal contrast provides lacking imaging functionality for large Si NPs and promises the development of novel cancer theranostic modalities on their basis.
- ПубликацияТолько метаданныеLaser-Processed Nanosilicon: A Multifunctional Nanomaterial for Energy and Healthcare(2019) Singh, A.; Swihart, M. T.; Kabashin, A. V.; Zavestovskaya, I. N.; Prasad, P. N.; Кабашин, Андрей Викторович; Завестовская, Ирина НиколаевнаCopyright © 2019 American Chemical Society.This review describes promising laser-based approaches to produce silicon nanostructures, including laser ablation of solid Si targets in residual gases and liquids and laser pyrolysis of silane. These methods are different from, and complementary to, widely used porous silicon technology and alternative synthesis routes. One can use these methods to make stable colloidal dispersions of silicon nanoparticles in both organic and aqueous media, which are suitable for a multitude of applications across the important fields of energy and healthcare. Size tailoring allows production of Si quantum dots with efficient photoluminescence that can be tuned across a broad spectral range from the visible to near-IR by varying particle size and surface functionalization. These nanoparticles can also be integrated with other nanomaterials to make multifunctional composites incorporating magnetic and/or plasmonic components. In the energy domain, this review highlights applications to photovoltaics and photodetectors, nanostructured silicon anodes for lithium ion batteries, and hydrogen generation from water. Application to nanobiophotonics and nanomedicine profits from the excellent biocompatibility and biodegradability of nanosilicon. These applications encompass several types of bioimaging and various therapies, including photodynamic therapy, RF thermal therapy, and radiotherapy. The review concludes with a discussion of challenges and opportunities in the applications of laser-processed nanosilicon.
- ПубликацияТолько метаданныеNovel advanced nanotechnologies for nuclear medicine(2021) Zavestovskaya, I. N.; Grigorieva, M.; Deyev, S. M.; Kabashin, A. V.; Завестовская, Ирина Николаевна; Григорьева, Мария Сергеевна; Деев, Сергей Михайлович; Кабашин, Андрей ВикторовичAbstract Nuclear nanomedicine forms a new research field based on the synergy of nuclear medicine and nanotechnology and implying the use of nanomaterials as carriers of diagnostic or therapeutic radionuclides. Such an approach promises a series of advantages over classical methods of nuclear medicine, including an increased surface area-to-volume ratio, passive/active delivery, high loading capacity, large cross-section in interactions with biological tissues, and unique properties of nanomaterials that make possible many functionalities within one construct. In this short review article, we will highlight our recent achievements in the development of nuclear nanomedicine technologies, which promise the advancement of methods for cancer treatment.
- ПубликацияТолько метаданныеLaser-ablative synthesis of nanomaterials for nuclear and radiative medicine applications(2022) Tikhonowski, G. V.; Popov, A. A.; Zelepukin, I.; Popova-Kuznetsova, E.; Dombrovska, Y.; Deyev, S. M.; Zavestovskaya, I. N.; Klimentov, S. M.; Prasad, P. N.; Kabashin, A. V.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Попова-Кузнецова, Елена Алефтиновна; Деев, Сергей Михайлович; Завестовская, Ирина Николаевна; Климентов, Сергей Михайлович; Кабашин, Андрей ВикторовичNewly emerging nanomaterials promise a major advancement of methods of nuclear and radiative medicine for cancer treatment, as they can be used as carriers of diagnostic or therapeutic radionuclides, contrast agents in nuclear imaging modalities (PET, SPECT) or sensitizers of radiative therapies (X-ray, ion beams, etc.). However, nanotechnology-based approaches have reported a limited success so far due to a lack of suitable functional nanoformulations, which are safe, non-toxic, excretable from the body and have favorable pharmacokinetics for effective accumulation in the tumor. As follows from the results of our on-going research activities, many of the above-stated problems can we solved by the employment of nanomaterials fabricated by clean laser-ablative synthesis. Here, we review our recent data on some promising nanomaterials, prepared by this method, including biodegradable silicon (Si) nanoparticles (NPs), Sm-152-enriched samarium oxide NPs, and elemental bismuth (Bi) NPs, which can be used either as carriers/agents in radionuclide therapy, or sensitizers in radiative diagnostics or therapy. Advantages of proposed approach include exceptional purity and flexibility in synthesizing of NPs of required physico-chemical parameters (controlled size, shape, composition, and surface conditioning of NPs). Advances in laser-ablative fabrication of novel nanomaterials open up avenues for future implementations of nuclear and radiative medicine approaches for safe and efficient theranostics of tumors and metastasis.
- ПубликацияТолько метаданныеTransforming Nuclear Medicine with Nanoradiopharmaceuticals(2022) Roy, I.; Krishnan, S.; Kabashin, A. V.; Zavestovskaya, I. N.; Prasad, P. N.; Кабашин, Андрей Викторович; Завестовская, Ирина Николаевна© 2022 American Chemical Society.Nuclear medicine is expected to make major advances in cancer diagnosis and therapy; tumor-targeted radiopharmaceuticals preferentially eradicate tumors while causing minimal damage to healthy tissues. The current scope of nuclear medicine can be significantly expanded by integration with nanomedicine, which utilizes nanoparticles for cancer diagnosis and therapy by capitalizing on the increased surface area-to-volume ratio, the passive/active targeting ability and high loading capacity, the greater interaction cross section with biological tissues, the rich surface properties of nanomaterials, the facile decoration of nanomaterials with a plethora of functionalities, and the potential for multiplexing several functionalities within one construct. This review provides a comprehensive discussion of nuclear nanomedicine using tumor-targeted nanoparticles for cancer radiation therapy with either pre-embedded radionuclides or nonradioactive materials which can be extrinsically triggered using various external nuclear particle sources to produce in situ radioactivity. In addition, it describes the prospect of combining nuclear nanomedicine with other modalities to enable synergistically enhanced combination therapies. The review also discusses advances in the fabrication of radionuclides as well as describes laser ablation technologies for producing nanoradiopharmaceuticals, which combine the ease of production with exceptional purity and rapid biodegradability, along with additional imaging or therapeutic functionalities. From a practical standpoint, these attributes of nanoradiopharmaceuticals may provide distinct advantages in diagnostic/therapeutic sensitivity and specificity, imaging resolution, and scalability of turnkey platforms. Coupling image-guided targeted radiation therapy with the possibility of in situ activation of nanomaterials as well as combining with other therapeutic modalities using a multifunctional nanoplatform could herald an era of exciting technological and therapeutic advances to radically transform the landscape of nuclear medicine. The review concludes with a discussion of current challenges and presents the authors' views on future opportunities to stimulate further research in this rewarding field of high societal impact.
- ПубликацияТолько метаданныеThe Atomistic Perspective of Nanoscale Laser Ablation(2023) Ivanov, D. S.; Terekhin, P. N.; Kudryashov, S. I.; Klimentov, S. M.; Kabashin, A. V.; Zavestovskaya, I. N.; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович; Завестовская, Ирина Николаевна
- ПубликацияТолько метаданныеLaser-synthesized plasmonic HfN-based nanoparticles as a novel multifunctional agent for photothermal therapy(2024) Pastukhov, A. I.; Savinov, M. S.; Zelepukin, I. V.; Babkova, J. S.; Tikhonowski, G. V.; Popov, A. A.; Klimentov, S. M.; Zavestovskaya, I. N.; Deyev, S. M.; Kabashin, A. V.; Савинов, Максим Сергеевич; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Деев, Сергей Михайлович; Кабашин, Андрей ВикторовичHfN nanoparticles exhibiting a tunable plasmonic feature in the near-IR were synthesized by laser ablation in liquids. A strong photothermal therapeutic effect yielding 100% cells death under 808 nm irradiation of nanoparticles was reported.