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Лощенов, Максим Викторович

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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Максим Викторович
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2022 - 20244
31
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Автор: Loshchenov, M. ×

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  • Уменьшенное изображение
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    3D bladder models for fluorescence imaging on bimodal system
    (2022) Kozlikina, E.; Kalyagina, N.; Loshchenov, M.; Efendiev, K.; Borodkin, A.; Калягина, Нина Анатольевна; Лощенов, Максим Викторович; Эфендиев, Канамат Темботович; Бородкин, Александр Викторович
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    Comparison of the Capabilities of Spectroscopic and Quantitative Video Analysis of Fluorescence for the Diagnosis and Photodynamic Therapy Control of Cholangiocellular Cancer
    (2022) Yakovlev, D.; Shiryaev, A.; Farrakhova, D.; Zhemerikin, G.; Savelieva, T.; Efendiev, K.; Loshchenov, M.; Савельева, Татьяна Александровна; Эфендиев, Канамат Темботович; Лощенов, Максим Викторович
    © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Cholangiocellular cancer (CCC) is a malignant neoplasm of the hepatobiliary system that is difficult to diagnose and treat. Currently, the most effective treatment of CCC is demonstrated under the control by fluorescent diagnosis. Photodynamic therapy (PDT) has also shown good results in the treatment of this disease, and fluorescence analysis of the photosensitizer is a good approach to control PDT. This article presents the results of a comparison of spectroscopic and quantitative video-fluorescent analysis of chlorin e6 photosensitizer fluorescence in vivo during cholangiocellular cancer surgery. Spectroscopic analysis provides accurate information about the concentration of the photosensitizer in the tumor, while the video-fluorescence method is convenient for visualizing tumor margins. A direct correlation is shown between these two methods when comparing the fluorescence signals before and after PDT. The applied paired Student’s t-test shows a significant difference between fluorescence signal before and after PDT in both diagnostic methods. In this regard, video-fluorescence navigation is not inferior in accuracy, sensitivity, or efficiency to spectroscopic methods.
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    Comparison of chlorin-e6 detection efficiency by video systems with excitation wavelengths of 405nm and 635nm
    (2023) Udeneev, A.; Kulichenko, A.; Kalyagina, N.; Plotnikova, A.; Loshchenov, M.; Калягина, Нина Анатольевна; Лощенов, Максим Викторович
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    Validation of a White Light and Fluorescence Augmented Panoramic Endoscopic Imaging System on a Bimodal Bladder Wall Experimental Model
    (2024) Moskalev, A.; Kalyagina, N.; Kozlikina, E.; Loshchenov, M.; Калягина, Нина Анатольевна; Лощенов, Максим Викторович
    Background: Fluorescence visualization of pathologies, primarily neoplasms in human internal cavities, is one of the most popular forms of diagnostics during endoscopic examination in medical practice. Currently, visualization can be performed in the augmented reality mode, which allows to observe areas of increased fluorescence directly on top of a usual color image. Another no less informative form of endoscopic visualization in the future can be mapping (creating a mosaic) of the acquired image sequence into a single map covering the area under study. The originality of the present contribution lies in the development of a new 3D bimodal experimental bladder model and its validation as an appropriate phantom for testing the combination of bimodal cystoscopy and image mosaicking. Methods: An original 3D real bladder-based phantom (physical model) including cancer-like fluorescent foci was developed and used to validate the combination of (i) a simultaneous white light and fluorescence cystoscopy imager with augmented reality mode and (ii) an image mosaicking algorithm superimposing both information. Results: Simultaneous registration and real-time visualization of a color image as a reference and a black-and-white fluorescence image with an overlay of the two images was made possible. The panoramic image build allowed to precisely visualize the relative location of the five fluorescent foci along the trajectory of the endoscope tip. Conclusions: The method has broad prospects and opportunities for further developments in bimodal endoscopy instrumentation and automatic image mosaicking.