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Семенова, Татьяна Алексеевна

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Институт общей профессиональной подготовки (ИОПП)
Миссией Института является: фундаментальная базовая подготовка студентов, необходимая для получения качественного образования на уровне требований международных стандартов; удовлетворение потребностей обучающихся в интеллектуальном, культурном, нравственном развитии и приобретении ими профессиональных знаний; формирование у студентов мотивации и умения учиться; профессиональная ориентация школьников и студентов в избранной области знаний, формирование способностей и навыков профессионального самоопределения и профессионального саморазвития. Основными целями и задачами Института являются: обеспечение высококачественной (фундаментальной) базовой подготовки студентов бакалавриата и специалитета; поддержка и развитие у студентов стремления к осознанному продолжению обучения в институтах (САЕ и др.) и на факультетах Университета; обеспечение преемственности образовательных программ общего среднего и высшего образования; обеспечение высокого качества довузовской подготовки учащихся Предуниверситария и школ-партнеров НИЯУ МИФИ за счет интеграции основного и дополнительного образования; учебно-методическое руководство общеобразовательными кафедрами Института, осуществляющими подготовку бакалавров и специалистов по социо-гуманитарным, общепрофессиональным и естественнонаучным дисциплинам, обеспечение единства требований к базовой подготовке студентов в рамках крупных научно-образовательных направлений (областей знаний).
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Татьяна Алексеевна
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    Opportunities for preeclampsia prevention: Today and tomorrow
    (2021) Guryeva, V. M.; Travkina, A. A.; Matveev, M. O.; Morokhotova, L. S.; Semenova, T. A.; Семенова, Татьяна Алексеевна
    © 2020 Trylyst. All rights reserved.Purpose of this review was to highlight the current and future possibilities of medicine in prevention of preeclampsia (PE) and placenta-associated complications (PAO). PE remains one of the most important causes of maternal and perinatal morbidity and mortality, and is responsible for the mass of premature births. The urgency of PE and PAO problem is primarily due to the lack of effective treatment for extensive clinical symptoms, as well as need to terminate pregnancy regardless of the gestational age and prognosis for fetus. In this regard, PE prevention is of great importance for clinical practice. This review presents the modern concept of PE pathogenesis, highlights the key points of hemostatic system disorders, leading to the clinical symptoms and PE. It was also shown that the imbalance between thromboxane and endothelial prostacyclin as well as between pro- A nd anti-angiogenic factors in pregnant women with PE can be considered as a therapeutic target in PE prevention and treatment; prescription of antiplatelet agents and anticoagulants for PE prevention is justified. Modern systematic reviews and meta-analysis have shown some effectiveness of antiplatelet agents and anticoagulants in PAO prevention. This review highlights the role of some nutrient deficiencies in the development of PAO and folate supplementation for their prevention. Presented data indicate that today there are methods for PAO prevention, which can significantly reduce their probability by 17-30% in pregnant women with a high risk of this obstetric pathology. However, a complete prevention and effective treatment of PAO at the stage of advanced clinical symptoms has not yet been developed, which leads to early termination of pregnancy, perinatal morbidity and mortality. Therefore, the development of new therapies that completely prevent or cure PE would be a major advance for practical obstetrics. This review presents the main scientific developments in this direction, in particular, clinical trials of drugs that can reduce sFlt-1 and soluble endoglin secretion, thus curing endothelial dysfunction in PE.
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    Clinical significance of sflt-1/plgf in the diagnosis and prediction of preeclampsia
    (2021) Guryeva, V. M.; Travkina, A. A.; Matveev, M. O.; Morokhotova, L. S.; Semenova, T. A.; Семенова, Татьяна Алексеевна
    © A group of authors, 2021.The diagnosis of preeclampsia in clinical practice causes certain difficulties due to the non-specificity of symptoms, the polymorphism of the clinical picture, and the discrepancy between the magnitude of clinical symptoms and the severity of multiple organ dysfunction. Therefore, the accurate diagnosis and prediction of preeclampsia is of great importance for practical obstetrics. The paper presents the results of the basic studies devoted to the clinical interpretation of the sFlt-1/PlGF ratio for the diagnosis and prediction of preeclampsia and shows the informative value and significance of the ratio for the objectification of the diagnosis of preeclampsia, as well as the possibility of predicting this obstetric complication according to sFlt-1/PlGF data. It shows the experience of using sFlt-1/ PlGF in the obstetric service in the Moscow Region and formulates indications for the study of sFlt-1/PlGF in clinical practice and approaches to its interpretation. Conclusion. The application of sFlt-1/PlGF allows the differential diagnosis of preeclampsia with an exacerbation or a manifestation of a number of somatic diseases that occur with similar clinical symptoms. The use of sFlt-1/PlGF provides an economic effect, by improving the routing and decreasing the number of severe perinatal and maternal outcomes, as well as reducing unjustified hospitalization. sFlt-1/PlGF is an informative marker for the diagnosis and prediction of preeclampsia and its adverse outcomes and can be recommended for use in clinical practice.