Персона: Ахлюстина, Екатерина Витальевна
Загружается...
Email Address
Birth Date
Научные группы
Научная группа
Организационные подразделения
Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
Статус
Фамилия
Ахлюстина
Имя
Екатерина Витальевна
Имя
3 results
Результаты поиска
Теперь показываю 1 - 3 из 3
- ПубликацияТолько метаданныеSTUdy OF ENERGy TRANSFER pROCESSES BETWEEN RARE EARTh IONS ANd phOTOSENSITIZER mOLECULES FOR phOTOdyNAmIC ThERApy WITh IR-EXCITATION ИССЛЕдОвАНИЕ пРОЦЕССОв пЕРЕдАчИ ЭНЕРГИИ мЕЖдУ РЕдКОЗЕмЕЛЬНЫмИ ИОНАмИ И мОЛЕКУЛАмИ фОТОСЕНСИБИЛИЗАТОРОв дЛя ЗАдАч фОТОдИНАмИчЕСКОи ТЕРАпИИ С вОЗБУЖдЕНИЕм в ИК-дИАпАЗОНЕ(2021) Proydakova, V. Y.; Romanishkin, I. D.; Kuznetsov, S. V.; Lukyanets, E. A.; Pominova, D. V.; Bogatova, A. S.; Akhlyustina, E. V.; Saveleva, T. A.; Loschenov, V. B.; Поминова, Дарья Вячеславовна; Ахлюстина, Екатерина Витальевна; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович© 2021 Russian Photodynamic Association. All rights reserved.Today, photodynamic therapy is one of the most promising minimally invasive methods of treatment of various diseases, including cancer. The main limitation of this method is the insufficient penetration into the tissue of laser radiation used to activate photosensitizer molecules,which makes it difficult to carry out therapy in the treatment of large or deep-seated tumors. In this regard, there is a great interest in thedevelopment of new strategies for photodynamic therapy using infrared radiation for excitation, the wavelengths of which fall into the “transparencywindow” of biological tissues. In this work, it was proposed to use upconversion NaGdF4:Yb:Er nanoparticles (UCNP), which absorbinfrared excitation and serve as a donor that transfers energy to the photosensitizer. Photosens and phthalosens were chosen as the mostpromising photosensitizers for the study. The aim of this work was to study the energy transfer processes between upconversion nanoparticlesdoped with rare-earth ions and photosensitizer molecules. in order to excite photosensitizers with IR radiation and carry out photodynamictherapy of deep-seated neoplasms. Using spectroscopic and time-resolved methods, it has been demonstrated that there is an efficientenergy transfer between upconversion particles and photosensitizers phthalosens and photosens. The calculated efficiency of energy transferby the Foerster mechanism was 41% for the UCNP + photosens system and 69% for the UCNP + phthalosens system. It has been experimentallyand theoretically proved that there is a binding of photosensitizer molecules with UCNP by means of surfactants, leading to a reductionin the distance between them, due to which effective nonradiative energy transfer is realized. The generation of singlet oxygen by the phthalosensphotosensitizer upon excitation by means of energy transfer from UCNP, excited at 980 nm wavelength of, has been demonstrated.
- ПубликацияТолько метаданныеNovel polycationic photosensitizers for antibacterial photodynamic therapy(2020) Tiganova, I. G.; Lukyanets, E. A.; Makarova, E. A.; Tolordava, E. R.; Meerovich, G. A.; Akhlyustina, E. V.; Loschenov, V. B.; Меерович, Геннадий Александрович; Ахлюстина, Екатерина Витальевна; Лощенов, Виктор Борисович© Springer Nature Switzerland AG 2019.Antibacterial photodynamic therapy (APDT) is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without them developing resistance in response to treatment. This work was dedicated to the study of photophysical and antibacterial properties of new photosensitizers (PS) based on polycationic phthalocyanines and synthetic bacteriochlorins for photodynamic inactivation of P. aeruginosa bacteria and their biofilms. Gram-negative bacteria P. aeruginosa are often found in infected wounds, presumably in biofilm state and are characterized by rather low susceptibility to APDT, which is a problem. PS were studied for possible aggregation at various concentrations by means of absorption and fluorescence spectroscopy. The results of studies of the ZnPcChol8, (3-PyHp)4BCBr4 and (3-PyEBr)4BCBr4 in water and serum confirm the assumption of a low degree of their aggregation at high concentrations. Consequently, their photodynamic efficiency is high enabling to use these PS at high concentrations to sensitize pathological foci for APDT. It was shown that all the investigated PS had a high efficiency of photodynamic inactivation of Gram-negative bacteria P. aeruginosa, as well as their biofilms. Tetracationic hydrophilic near-infrared photosensitizer (3-PyEBr)4BCBr4 with reduced molecule size had significantly higher efficacy of photodynamic inactivation of P. aeruginosa biofilms compared with other studied photosensitizers.
- ПубликацияТолько метаданныеPhotodynamic inactivation of Pseudomonas aeruginosa bacterial biofilms using new polycationic photosensitizers(2019) Tiganova, I. G.; Lukyanets, E. A.; Makarova, E. A.; Tolordava, E. R.; Meerovich, G. A.; Akhlyustina, E. V.; Gonchukov, S. A.; Loschenov, V. B.; Меерович, Геннадий Александрович; Ахлюстина, Екатерина Витальевна; Гончуков, Сергей Александрович; Лощенов, Виктор Борисович© 2019 Astro Ltd.The treatment of infected, long-term, non-healing, complicated wounds of the skin and mucosa, trophic ulcers, pressure sores and ulcers of diabetic feet represents a serious problem, especially in the case of resistant and multi-resistant pathogens. Antibacterial photodynamic therapy can be a promising method of local infected foci treatment of such diseases. This work is devoted to the study of the possibility of photodynamic inactivation (PDI) of Pseudomonas aeruginosa bacteria in the form of biofilms with the help of new polycationic photosensitizers (PSs) based on octacationic phthalocyanine and tetra-and octabacteriochlorins (ZnPcChol8, (3-PyBrE)4BCBr4 and (3-PyEPy)4BCBr8). More specifically, this work aims to clarify the role of light irradiation in PDI with the participation of new PSs, which has not been fully studied, especially with respect to the comparison of different PS types.