2019, Tiganova, I. G., Lukyanets, E. A., Makarova, E. A., Tolordava, E. R., Meerovich, G. A., Akhlyustina, E. V., Gonchukov, S. A., Loschenov, V. B., Меерович, Геннадий Александрович, Ахлюстина, Екатерина Витальевна, Гончуков, Сергей Александрович, Лощенов, Виктор Борисович

© 2019 Astro Ltd.The treatment of infected, long-term, non-healing, complicated wounds of the skin and mucosa, trophic ulcers, pressure sores and ulcers of diabetic feet represents a serious problem, especially in the case of resistant and multi-resistant pathogens. Antibacterial photodynamic therapy can be a promising method of local infected foci treatment of such diseases. This work is devoted to the study of the possibility of photodynamic inactivation (PDI) of Pseudomonas aeruginosa bacteria in the form of biofilms with the help of new polycationic photosensitizers (PSs) based on octacationic phthalocyanine and tetra-and octabacteriochlorins (ZnPcChol8, (3-PyBrE)4BCBr4 and (3-PyEPy)4BCBr8). More specifically, this work aims to clarify the role of light irradiation in PDI with the participation of new PSs, which has not been fully studied, especially with respect to the comparison of different PS types.

2022, Kogan, E. A., Karshieva, S. S., Makarova, E. A., Dalina, A. A., Meerovich, G. A., Akhlyustina, E. V., Gonchukov, S. A., Loschenov, V. B., Меерович, Геннадий Александрович, Ахлюстина, Екатерина Витальевна, Гончуков, Сергей Александрович, Лощенов, Виктор Борисович

© 2022 Astro Ltd.In view of their potential in the treatment of oncological diseases, photosensitizers (PS) have been the object of active research for the last years. The applied therapeutic photodynamic method involves the activation of a PS by light at a specific wavelength. PS interacts with oxygen and catalyzes the production of singlet oxygen molecules or radical oxygen species which leads to tumor cell death. This work is devoted to the study of the effectiveness of the photodynamic action of new PSs based on polycationic derivatives of synthetic bacteriochlorin on human lung cancer cells A549. The results obtained show that these PS effectively bind to these cells, have high phototoxicity and low 'dark' cytotoxicity for them. Morphological and immunohistochemical studies show that photodynamic effect leads to induction of cell necrosis and apoptosis, as well as a sharp decrease in mitotic activity.