Персона: Набиев, Игорь Руфаилович
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Игорь Руфаилович
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- ПубликацияТолько метаданныеTwo-photon-activated light energy conversion in quantum dot-purple membrane hybrid material(2019) Krivenkov, V. A.; Samokhvalov, P. S.; Nabiev, I.; Самохвалов, Павел Сергеевич; Набиев, Игорь РуфаиловичThe photosensitive protein bacteriorhodopsin (bR) has been shown to be a promising material for optoelectronic and photovoltaic applications, but it cannot effectively absorb and utilize light energy in the near-infrared (NIR) region of the optical spectrum. Semiconductor quantum dots (QDs) have two-photon absorption cross-sections two orders of magnitude larger than those of bR and can effectively transfer the up-converted energy of two NIR photons to bR via the Forster resonance energy transfer (FRET). In this study we fabricated a hybrid material in the form of an aqueous solution of electrostatically bound complexes of QDs and purple membranes (PMs) containing bR. Efficient FRET from QDs to bR was observed in these complexes under selective two-photon excitation of QDs. Then, we fabricated a photoelectrochemical cell operating in the NIR spectral region. Measurement of the photoelectrical signals from the cell containing pure PMs, or QD-PM hybrid material has shown that the light conversion in the QD-PM hybrid material with 3:1 bR-to-QD molar ratio is more efficient than in the material with 20:1 bR-to-QD molar ratio. The results of this study may extend the use of bioinspired hybrid materials in optoelectronics, holography, and bioenergetics under the conditions of nonlinear excitation.
- ПубликацияТолько метаданныеResonance energy transfer from quantum dots to bacteriorhodopsin affects the saturation of two-photon absorption under a pulsed femtosecond excitation(2019) Krivenkov, V. A.; Samokhvalov, P. S.; Chistyakov, A. A.; Nabiev, I.; Самохвалов, Павел Сергеевич; Чистяков, Александр Александрович; Набиев, Игорь РуфаиловичSemiconductor quantum dots (QDs) have high two-photon absorption cross-sections and long photoluminescence (PL) lifetimes, which make them a promising photosensitive part for fabrication of QD-based hybrid materials for two-photon bio-imaging, bio- and optoelectronics. In these areas, mode-locked femtosecond lasers are often used for two-photon excitation of QDs because of the high peak intensity of the laser pulse. However, the QD radiative lifetime usually exceeds the period between the laser pulses of such laser systems, which can affect the absorption and PL properties of QDs. In this work, we investigated the PL properties of CdSe/ZnS QDs under two-photon excitation. We have shown that using femtosecond laser excitation at a wavelength of 790 nm with a pulse repetition rate of 80 MHz and a peak intensity of more than 10 GW/cm(2), the two-photon absorption in QD is saturated. However if QDs were in complexes with purple membranes (PM) containing the photosensitive protein bacteriorhodopsin (bR), saturation was not observed up to an intensity of about 27 GW/cm(2). It was concluded that the difference in the saturation of two-photon absorption between QDs and QD-PM material is associated with the Forster resonance energy transfer from QD to bR and the corresponding shortening of the PL lifetime. The results obtained will allow to optimize the two-photon excitation regime of QD-PM nano-bio hybrid material which will expand the possible areas of its application in bio-imaging, bio- and optoelectronics.
- ПубликацияТолько метаданныеNanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays(2019) Ramos-Gomes, F.; Chames, P.; Baty, D.; Alves, F.; Sukhanova, A.; Samokhvalov, P.; Nabiev, I.; Суханова, Алена Владимировна; Самохвалов, Павел Сергеевич; Набиев, Игорь Руфаилович© 2019 SPIE.Semiconductor quantum dots (QDs) are characterized by orders of magnitude higher multiphoton linear absorption cross-sections compared with conventional organic dyes. Combined with the QD photoluminescence quantum yield approaching 100%, this fact opens great prospects for the twophoton functional tumor imaging with QDs tagged with highly specific recognition molecules. Single-domain antibodies (sdAbs) or "nanobodies" derived from lamas are the smallest high-affinity recognition molecules, which may be tagged with the QDs thus permitting not only solid tumors multiphoton imaging but also rare disseminated cancer cells and micrometastases in the depth of the tissue to be detected. Additionally, unique photostability of QDs enables signal accumulation and significant enhancement of the sensitivity of routine biochemical and immunohistochemical assays to be obtained when the conjugates of QDs, instead of organic dyes, are used.
- ПубликацияТолько метаданныеEngineering of fluorescent biomaging tools for cancer cell targeting based on polyelectrolyte microcapsules encoded with quantum dots(2019) Ramos-Gomes, F.; Alves, F.; Sukhanova, A.; Nifontova, G.; Baryshnikova, M.; Nabiev, I.; Нифонтова, Галина Олеговна; Барышникова, Мария Анатольевна; Набиев, Игорь Руфаилович© 2019 SPIE.Quantum dots (QDs) are fluorescent semiconductor nanocrystals with a high photostability, wide absorption spectra, and narrow, size-tunable emission spectra, which make them promising nanolabels to be encapsulated in microcarriers used as bioimaging and theranostic tools. Here, we describe an approach to the optical encoding of polyelectrolyte microcapsules with the prepared stable water-soluble QDs and key stages of surface functionalization of these microcapsules with cetuximab, humanised monoclonal anticancer antibody. Obtained conjugates demonstrate the specificity and efficiency of the engineered system as a cancer cell-targeted tracing tool that could be used for cancer diagnosis, treatment and monitoring of cancer therapy.
- ПубликацияТолько метаданныеModification of multiphoton emission properties of single quantum dot due to the long-range coupling with plasmon nanoparticles in thin-film hybrid material(2019) Sanchez-Iglesias, A.; Grzelczak, M.; Krivenkov, V.; Samokhvalov, P.; Nabiev, I.; Rakovich, Y.; Самохвалов, Павел Сергеевич; Набиев, Игорь Руфаилович© 2019 SPIE.Semiconductor quantum dots (QDs) are known for their unique photophysical properties and, in particular, their ability to multiphoton emission caused by recombination of biexcitons. However, the luminescence quantum yield of biexciton states is relatively low due to the fast Auger non-radiative process. Plasmonic nanoparticles can significantly accelerate the radiative rate of QDs. In this study we demonstrate the distance-controlled enhancement of the biexciton emission of single CdSe/ZnS/CdS/ZnS QDs due to their coupling with gold nanorods. We explain this enhancement as the distancedependent trade-off between the energy transfer and the Purcell effect. Our findings constitute a reliable approach to managing the efficiency of multiphoton emission over a wide span of distances.
- ПубликацияТолько метаданныеPolariton-assisted emission of strongly coupled organic dye excitons in a tunable optical microcavity(2019) Mochalov, K.; Dovzhenko, D.; Vaskan, I.; Kryukova, I.; Rakovich, Y.; Nabiev, I.; Крюкова, Ирина Сергеевна; Набиев, Игорь Руфаилович© 2019 SPIE.Light-matter coupling between the molecular dipole transitions and a confined electromagnetic field provides the ability to control the fundamental properties of coupled matter. The use of tunable optical microcavities for electromagnetic field confinement allows one to affect the coupled state properties in a controllable manner, whereas the coupling strength in this system strongly depends on the transition dipole moment and a mode volume of the cavity. In this study we have demonstrated controllable emission of Rhodamine 6G organic molecules with relatively low and unoriented dipole moments in a strong coupling regime by placing them into a tunable Fabry-Perot microcavity.
- ПубликацияТолько метаданныеEnergy transfer mechanisms in nanobiohybrid structures based on quantum dots and photosensitive membrane proteins(2016) Sizova, S. V.; Oleinikov, V. A.; Bouchonville, N.; Molinari, M.; Samokhvalov, P. S.; Sukhanova, A.; Nabiev, I.; Суханова, Алена Владимировна; Набиев, Игорь Руфаилович; Олейников, Владимир АлександровичThe integration of novel nanomaterials with highly functional biological molecules has numerous advanced applications, including optoelectronics, biosensing, imaging, and energy harvesting. This review summarizes recent progress in understanding the mechanisms of energy transfer between semiconductor nanocrystal (so-called quantum dots [QDs]) and photosensitive proteins in heterostructures, such as hybrids of semiconductor nanocrystals with purple membranes containing bacteriorhodopsin (bR) or with photosynthetic reaction centers (RCs). Understanding of these mechanisms should enable prediction of the possible ways to improve the biological function of biomolecules by means of their assembling with QDs and develop novel functional materials with controlled photonic properties and applications. The possible mechanisms of energy transfer from QDs to photochromic biomolecules are discussed and correlated with experimental data. The principles of hybrid structures engineering, donor/acceptor parameters affecting both energy transfer efficiency and biological function, and functionality of these hybrid structures are described. New nanobiohybrid materials are shown to have advanced implications for optoelectronics, photonics, and photovoltaics due to the ability of nanocomponents of these materials for efficient energy harvesting, conversion, and transfer of additional energy to Biosystems, thus making them working more efficiently.
- ПубликацияТолько метаданныеOptical Properties of Quantum Dots with a Core–Multishell Structure(2019) Linkov, P.; Samokhvalov, P.; Vokhmintsev, K.; Zvaigzne, M.; Krivenkov, V. A.; Nabiev, I.; Самохвалов, Павел Сергеевич; Набиев, Игорь Руфаилович© 2019, Pleiades Publishing, Inc. In the last decade, colloidal semiconductor nanocrystals (quantum dots) have been not only studied fundamentally but also applied in photovoltaics, optoelectronics, and biomedicine. Beginning with simple approaches to the deposition of protective shells, e.g., ZnS on CdSe cores, searches for ways to increase the quantum yield of photoluminescence of quantum dots have resulted now in the development of new types of quantum dots characterized not only by record high extinction coefficients but also by high photoluminescence quantum yields. In this work, the optical properties of core–multishell quantum dots have been analyzed. These quantum dots have been specially designed to reach the maximum possible localization of excited charge carriers inside luminescent cores, which makes it possible to reach a photoluminescence quantum yield close to 100%. Core–multishell quantum dot samples with a shell thickness of 3–7 monolayers have been fabricated. Changes in the characteristics of optical transitions in such quantum dots with an increase in the number of layers of the shell have been studied. The effect of the thickness of the shell on the optical properties of prepared quantum dots has been analyzed. In particular, analysis of photoluminescence lifetimes of such quantum dots has revealed a possible alternative mechanism of radiation of core–multishell quantum dots based on the slow charge carrier transfer from the excited outer layer of the CdS shell to the CdSe core.
- ПубликацияТолько метаданныеSpectral and Spatial Characteristics of the Electromagnetic Modes in a Tunable Optical Microcavity Cell for Studying Hybrid Light-Matter States(2019) Moehalov, K. E.; Dovzhenko, D. S.; Vaskan, I. S.; Rakovich, Yu. P.; Nabiev, I. R.; Набиев, Игорь РуфаиловичStudies of resonance interaction between matter and localized electromagnetic field in a cavity have recently attracted much interest because they offer the possibility of controllably modifying some of the fundamental material properties. However, despite the large number of such studies, these is no universal approach that would allow investigation of sets of different samples with wide variation of the main experimental parameters of the optical modes. In this work, the main optical parameters of a previously developed universal tunable microcavity cell, i.e., the Q factor and mode volume, as well as their dependence on the characteristics of cavity mirrors and spacing between them, are analyzed. The results obtained will significantly expand the scope of applications of resonance interaction between light and matter, including such effects as the enhancement of Raman scattering, long-range resonance nonradiative energy transfer, and modification of chemical reaction rates.
- ПубликацияТолько метаданныеScanning Near-Field Optical Nanospectrophotometry: a New Method for Nanoscale Measurements of the Absorption Spectra of Single Nanoobjects(2019) Mochalov, K. E.; Solovyeva, D. O.; Vaskan, I. S.; Nabiev, I. R.; Набиев, Игорь Руфаилович© 2019, Pleiades Publishing, Ltd. Abstract: A new experimental method for nanoscale measurements of the absorption spectra of single nanoobjects has been developed based on scanning near-field optical microspectroscopy (SNOM) and nanospectrophotometry (NSP). The main distinctive feature of the proposed SNOM-NSP technique consists in depositing a sample onto a coverglass followed by its probing in the total internal reflection spectroscopy mode. This approach allows the number of analyzed samples to be significantly increased and provides the possibility of combining measurements with other optical techniques. The proposed SNOM-NSP method has been successfully used for studying single plasmonic nanoparticles and their complexes with Rhodamine 6G dye.