2019, de, Menezes, F. D., dos, Reis, S. R. R., Pinto, S. R., Portilho, F. L., Sukhanova, A., Nabiev, I. R., Суханова, Алена Владимировна, Набиев, Игорь Руфаилович

© 2019 Graphene is one of the crystalline forms of carbon, along with diamond, graphite, carbon nanotubes, and fullerenes, and is considered as a revolutionary and innovating product. The use of a graphene-based nanolabels is one of the latest and most prominent application of graphene, especially in the field of diagnosis and, recently, in loco radiotherapy when coupled with radioisotopes. However, its biological behavior and mutagenicity in different cell or animal models, as well as the in vivo functional activities, are still unrevealed. In this study we have developed by a green route of synthesizing graphene quantum dots (GQDs)and characterized them. We have also developed a methodology for direct radiolabeling of GQDs with radioisotopes.Finally; we have evaluated in vivo biological behavior of GQDs using two different mice models and tested in vitro mutagenicity of GQDs. The results have shown that GQDs were formed with a size range of 160-280 nm, which was confirmed by DRX and Raman spectroscopy analysis, corroborating that the green synthesis is an alternative, environmentally friendly way to produce graphene. The radiolabeling test has shown that stable radiolabeled GQDs can be produced with a high yield (>90%). The in vivo test has demonstrated a ubiquitous behavior when administered to healthy animals, with a high uptake by liver (>26%)and small intestine (>25%). Otherwise, in an inflammation/VEGF hyperexpression animal model (endometriosis), a very peculiar behavior of GQDs was observed, with a high uptake by kidneys (over 85%). The mutagenicity test has demonstrated A:T to G:C substitutions suggesting that GQDs exhibits mutagenic activity.

2019, Samokhvalov, P. S., Volodin, D. O., Bozrova, S. V., Dovzhenko, D. S., Zvaigzne, M. A., Lin'kov, P. A., Nifontova, G. O., Petrova, I. O., Sukhanova, A. V., Nabiev, I. R., Самохвалов, Павел Сергеевич, Нифонтова, Галина Олеговна, Суханова, Алена Владимировна, Набиев, Игорь Руфаилович

© 2019, Pleiades Publishing, Ltd.Abstract: Plasmonic nanoparticles have become a popularly accepted research tool in optoelectronics, photonics, and biomedical applications. The relatively recently appearing semiconductor plasmonic nanoparticles, as opposed to metal ones, are characterized by infrared plasmonic optical transitions and their application has a great future. In this work, the possibility of conversion of semiconductor (excitonic) fluorescence nanocrystals, i.e., quantum dots of the CuInS2 composition, to plasmonic nanoparticles by postsynthetic treatment without changes in the chemical composition of inorganic part of the nanocrystals was demonstrated for the first time ever.

2019, Melnikau, D., Govyadinov, A. A., Sanchez-Iglesias, A., Grzelczak, M., Nabiev, I. R., Liz-Marzan, L. M., Rakovich, Y. P., Набиев, Игорь Руфаилович

Copyright © 2019 American Chemical Society.The interaction of several components in the strong coupling regime yielding multiple Rabi splittings opens up remarkable possibilities for studies of multimode hybridization and energy transfer, which is of considerable interest in both fundamental and applied science. Here we demonstrate that three different components, such as core-shell Au@Ag nanorods and J-aggregates of two different dyes, can be integrated into a single hybrid structure, which leads to strong collective exciton-plasmon coupling and double-mode Rabi splitting totaling 338 meV. We demonstrate strong coupling in these multicomponent plexitonic nanostructures by means of magnetic circular dichroism spectroscopy and demonstrate strong magneto-optical activity for the three hybridized states resulting from this coupling. The J-aggregates of two different nonmagnetic dyes interact with metal nanoparticles effectively, achieving magnetic properties due to the hybridization of electronic excitations in the three-component system. ©

2019, Moehalov, K. E., Dovzhenko, D. S., Vaskan, I. S., Rakovich, Yu. P., Nabiev, I. R., Набиев, Игорь Руфаилович

Studies of resonance interaction between matter and localized electromagnetic field in a cavity have recently attracted much interest because they offer the possibility of controllably modifying some of the fundamental material properties. However, despite the large number of such studies, these is no universal approach that would allow investigation of sets of different samples with wide variation of the main experimental parameters of the optical modes. In this work, the main optical parameters of a previously developed universal tunable microcavity cell, i.e., the Q factor and mode volume, as well as their dependence on the characteristics of cavity mirrors and spacing between them, are analyzed. The results obtained will significantly expand the scope of applications of resonance interaction between light and matter, including such effects as the enhancement of Raman scattering, long-range resonance nonradiative energy transfer, and modification of chemical reaction rates.

2019, Kosmyntseva, A. V., Petrova, I. O., Rakovich, Y. P., Sukhanova, A. V., Nabiev, I. R., Набиев, Игорь Руфаилович

Using fluorescence resonance energy transfer, the physical interaction of nanoparticles with biopolymers is studied by the example of the interaction of quantum dots (energy donor) with two-chain oligonucleotides labeled with a fluorescent organic dye BDP TR (energy acceptor). The high-efficiency resonance energy transfer from quantum dots to an organic dye not only makes it possible to study the dependence of the transfer efficiency on the donor-acceptor molar ratio but also represents an efficient tool for studying the interactions of oligonucleotides of different structures with nanoscale objects.

2020, Kryukova, I. S., Dovzhenko, D. S., Rakovich, Yu. P., Nabiev, I. R., Крюкова, Ирина Сергеевна, Набиев, Игорь Руфаилович

© Published under licence by IOP Publishing Ltd.Today, lots of research address the phenomenon of interaction between light and matter. In particular, it is of a special interest to investigate light-matter interaction in one-dimensional resonators based on porous materials. In this case, one can embed emitting semiconductor particles into the porous resonator, where the excitons of these particles couple to the resonator eigenmode and luminescence intensity of the emitters is enhanced, allowing an increase in the sensitivity of optical sensors, detectors, and photonic diagnostic assays. A particular challenge is to place the emitters directly in the antinode region of the resonator eigenmode in order to maximize the coupling strength, which is sometimes a problem due to the spatial distribution of emitters away from the eigenmode localization region. Here, we have shown that the transfer-printing technique can be used to obtain structures based on freestanding porous silicon photonic crystals capable of precisely controlling the emitter spatial distribution about the eigenmode localization region. This, as well as the porosity of these structures and high adsorption capacity of porous silicon, allows the light-matter interaction in these hybrid structures to be used in sensing applications. We have shown that the transfer-printing method does not worsen the optical properties of the microcavities compared to the conventional electrochemical etching of the whole microcavity at a time. Furthermore, we have observed slightly better coupling of the exciton of the emitter to the eigenmode of the transfer-printed microcavity in the weak coupling regime.

2019, Mochalov, K. E., Solovyeva, D. O., Vaskan, I. S., Nabiev, I. R., Набиев, Игорь Руфаилович

© 2019, Pleiades Publishing, Ltd. Abstract: A new experimental method for nanoscale measurements of the absorption spectra of single nanoobjects has been developed based on scanning near-field optical microspectroscopy (SNOM) and nanospectrophotometry (NSP). The main distinctive feature of the proposed SNOM-NSP technique consists in depositing a sample onto a coverglass followed by its probing in the total internal reflection spectroscopy mode. This approach allows the number of analyzed samples to be significantly increased and provides the possibility of combining measurements with other optical techniques. The proposed SNOM-NSP method has been successfully used for studying single plasmonic nanoparticles and their complexes with Rhodamine 6G dye.

2019, Efimov, A., Agapova, O., Agapov, I., Nifontova, G., Nabiev, I. R., Sukhanova, A., Нифонтова, Галина Олеговна, Набиев, Игорь Руфаилович, Суханова, Алена Владимировна

© 2019, The Author(s). Fluorescent imaging is a widely used technique for detecting and monitoring the distribution, interaction, and transformation processes at molecular, cellular, and tissue level in modern diagnostic and other biomedical applications. Unique photophysical properties of fluorescent semiconductor nanocrystals “quantum dots” (QDs) make them advanced fluorophores for fluorescent labeling of biomolecules or optical encoding of microparticles to be used as bioimaging and theranostic agents in targeted delivery, visualization, diagnostics, and imaging. This paper reports on the results of development of an improved approach to the optical encoding of polyelectrolyte microcapsules with stable, covered with the multifunctional polyethyleneglycol derivatives water-soluble QDs, as well as characterization of the optical properties, morphological and structural properties of the encoded microcapsules. The embedding of QDs into the polymer microcapsule membrane through layer-by-layer deposition on a preliminarily formed polymeric polyelectrolyte shell makes it possible to obtain bright fluorescent particles with an adapted charge and size distribution that are distinctly discernible by flow cytometry as individual homogeneous populations. The fluorescent microcapsules developed can be used in further designing bioimaging and theranostic agents sensitive to various external stimuli along with photoexcitation.