Персона: Завестовская, Ирина Николаевна
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Ирина Николаевна
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- ПубликацияТолько метаданныеStudy of IR Photoheating of Aqueous Solutions of Boron Nanoparticles Synthesized by Pulsed Laser Ablation for Cancer Therapy(2022) Belyaev, I. B.; Zelepukin, I. V.; Pastukhov, A. I.; Shakhov, P. V.; Tikhonowski, G. V.; Popov, A. A.; Zakharkiv, A. Y.; Klimentov, S. M.; Garmash, A. A.; Zavestovskaya, I. N.; Deyev, S. M.; Kabashin, A. V.; Шахов, Павел Владимирович; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Захаркив, Анастасия Юрьевна; Климентов, Сергей Михайлович; Гармаш, Александр Александрович; Завестовская, Ирина Николаевна; Деев, Сергей МихайловичAbstract: Photothermal properties of boron (B) nanoparticles (NPs) synthesized by pulsed laser ablation in liquid (PLAL) are studied. It is found that B NPs have high optical extinction coefficient in the near infrared (IR) region, in particular, its value was 0.2 l/(cm g) at a wavelength of 800 nm. It is shown that aqueous suspensions of B NPs can be heated during laser irradiation with a wavelength of 830 nm and a radiation power of 1 W. Here, the temperature increase varied from 6.5 to 36°C under the increase of the particle concentration from 0.04 to 0.8 g/L; while the relevant parameter in the absence of particles was 2°C. B NPs were able to provide a stable photothermal response during several irradiation cycles. The results evidence a high potential of B NPs as sensitizers of photothermal therapy (PTT). © 2022, Allerton Press, Inc.
- ПубликацияТолько метаданныеLaser-ablative aqueous synthesis and characterization of elemental boron nanoparticles for biomedical applications(2022) Pastukhov, A. I.; Belyaev, I. B.; Bulmahn, J. C.; Zelepukin, I. V.; Popov, A. A.; Zavestovskaya, I. N.; Klimentov, S. M.; Deyev, S. M.; Prasad, P. N.; Kabashin, A. V.; Попов, Антон Александрович; Завестовская, Ирина Николаевна; Климентов, Сергей Михайлович; Деев, Сергей Михайлович
- ПубликацияТолько метаданныеLaser-ablative synthesis of nanomaterials for nuclear and radiative medicine applications(2022) Tikhonowski, G. V.; Popov, A. A.; Zelepukin, I.; Popova-Kuznetsova, E.; Dombrovska, Y.; Deyev, S. M.; Zavestovskaya, I. N.; Klimentov, S. M.; Prasad, P. N.; Kabashin, A. V.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Попова-Кузнецова, Елена Алефтиновна; Деев, Сергей Михайлович; Завестовская, Ирина Николаевна; Климентов, Сергей Михайлович; Кабашин, Андрей ВикторовичNewly emerging nanomaterials promise a major advancement of methods of nuclear and radiative medicine for cancer treatment, as they can be used as carriers of diagnostic or therapeutic radionuclides, contrast agents in nuclear imaging modalities (PET, SPECT) or sensitizers of radiative therapies (X-ray, ion beams, etc.). However, nanotechnology-based approaches have reported a limited success so far due to a lack of suitable functional nanoformulations, which are safe, non-toxic, excretable from the body and have favorable pharmacokinetics for effective accumulation in the tumor. As follows from the results of our on-going research activities, many of the above-stated problems can we solved by the employment of nanomaterials fabricated by clean laser-ablative synthesis. Here, we review our recent data on some promising nanomaterials, prepared by this method, including biodegradable silicon (Si) nanoparticles (NPs), Sm-152-enriched samarium oxide NPs, and elemental bismuth (Bi) NPs, which can be used either as carriers/agents in radionuclide therapy, or sensitizers in radiative diagnostics or therapy. Advantages of proposed approach include exceptional purity and flexibility in synthesizing of NPs of required physico-chemical parameters (controlled size, shape, composition, and surface conditioning of NPs). Advances in laser-ablative fabrication of novel nanomaterials open up avenues for future implementations of nuclear and radiative medicine approaches for safe and efficient theranostics of tumors and metastasis.
- ПубликацияТолько метаданныеThe Atomistic Perspective of Nanoscale Laser Ablation(2023) Ivanov, D. S.; Terekhin, P. N.; Kudryashov, S. I.; Klimentov, S. M.; Kabashin, A. V.; Zavestovskaya, I. N.; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович; Завестовская, Ирина Николаевна
- ПубликацияТолько метаданныеLaser-synthesized plasmonic HfN-based nanoparticles as a novel multifunctional agent for photothermal therapy(2024) Pastukhov, A. I.; Savinov, M. S.; Zelepukin, I. V.; Babkova, J. S.; Tikhonowski, G. V.; Popov, A. A.; Klimentov, S. M.; Zavestovskaya, I. N.; Deyev, S. M.; Kabashin, A. V.; Савинов, Максим Сергеевич; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Деев, Сергей Михайлович; Кабашин, Андрей ВикторовичHfN nanoparticles exhibiting a tunable plasmonic feature in the near-IR were synthesized by laser ablation in liquids. A strong photothermal therapeutic effect yielding 100% cells death under 808 nm irradiation of nanoparticles was reported.
- ПубликацияТолько метаданныеBismuth nanoparticles-enhanced proton therapy: Concept and biological assessment(2024) Zavestovskaya, I. N.; Tikhonowski, G. V.; Savinov, M.; Shakhov, P. V.; Popov, A. A.; Klimentov, S. M.; Deyev, S. M.; Завестовская, Ирина Николаевна; Тихоновский, Глеб Валерьевич; Савинов, Максим Сергеевич; Шахов, Павел Владимирович; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович
- ПубликацияТолько метаданныеUltrafast laser ablation of gold in liquids: Effect of laser pulse overlap-induced surface porosity on size distribution of formed nanoparticles(2024) Ivanov, D. S.; Shakhov, P.; Tikhonowsky, G.; Popov, A. A.; Mayorov, A. N.; Zavestovskaya, I. N.; Klimentov, S. M.; Шахов, Павел Владимирович; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Майоров, Алексей Николаевич; Завестовская, Ирина Николаевна; Климентов, Сергей Михайлович
- ПубликацияТолько метаданныеBoron Nanoparticle-Enhanced Proton Therapy: Molecular Mechanisms of Tumor Cell Sensitization(2024) Popov, A. L.; Kolmanovich, D. D.; Chukavin, N. N.; Zelepukin, I. V.; Tikhonowski, G. V.; Popov, A. A.; Klimentov, S. M.; Deyev, S. M.; Zavestovskaya, I. N.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович; Завестовская, Ирина НиколаевнаBoron-enhanced proton therapy has recently appeared as a promising approach to increase the efficiency of proton therapy on tumor cells, and this modality can further be improved by the use of boron nanoparticles (B NPs) as local sensitizers to achieve enhanced and targeted therapeutic outcomes. However, the mechanisms of tumor cell elimination under boron-enhanced proton therapy still require clarification. Here, we explore possible molecular mechanisms responsible for the enhancement of therapeutic outcomes under boron NP-enhanced proton therapy. Spherical B NPs with a mode size of 25 nm were prepared by methods of pulsed laser ablation in water, followed by their coating by polyethylene glycol to improve their colloidal stability in buffers. Then, we assessed the efficiency of B NPs as sensitizers of cancer cell killing under irradiation with a 160.5 MeV proton beam. Our experiments showed that the combined effect of B NPs and proton irradiation induces an increased level of superoxide anion radical generation, which leads to the depolarization of mitochondria, a drop in their membrane mitochondrial potential, and the development of apoptosis. A comprehensive gene expression analysis (via RT-PCR) confirmed increased overexpression of 52 genes (out of 87 studied) involved in the cell redox status and oxidative stress, compared to 12 genes in the cells irradiated without B NPs. Other possible mechanisms responsible for the B NPs-induced radiosensitizing effect, including one related to the generation of alpha particles, are discussed. The obtained results give a better insight into the processes involved in the boron-induced enhancement of proton therapy and enable one to optimize parameters of proton therapy in order to maximize therapeutic outcomes.
- ПубликацияТолько метаданныеColloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine(2020) Duflot, V. R.; Popova-Kuznetsova, E.; Tikhonowski, G.; Popov, A. A.; Deyev, S. M.; Klimentov, S. M.; Zavestovskaya, I. N.; Prasad, P. N.; Kabashin, A. V.; Попова-Кузнецова, Елена Алефтиновна; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Деев, Сергей Михайлович; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Кабашин, Андрей Викторович© 2020 SPIE.Nanotechnology promises a major improvement of efficacy of nuclear medicine by targeted delivery of radioactive agents to tumors, but this approach still needs novel efficient nanoformulations to maximize diagnostic and therapeutic functions. Here, we present a two-step method of laser ablation and fragmentation in water to produce non-radioactive 152Sm-enriched samarium oxide nanoparticles (Sm NPs), which can be converted to radioactive form of 153Sm beta-emitters by neutron capture reaction. We found that laser ablation in deionized water leads to the formation of NPs having diverse morphology and broad size dispersion. To improve size characteristics of formed NPs, we applied additional femtosecond laser fragmentation step, which made possible a good control of mean NPs size under a drastic narrowing of size dispersion, and the spherical shape of formed NPs. Obtained colloidal solutions of Sm NPs were stable for several weeks after the synthesis. The formed NPs present a very promising object for nuclear nanomedicine.
- ПубликацияТолько метаданныеNanoparticles based on MIL-101 metal-organic frameworks as efficient carriers of therapeutic188Re radionuclide for nuclear medicine(2024) Belyaev, I. B.; Zelepukin, I. V.; Petriev, V. M.; Klimentov, S. M.; Zavestovskaya, I. N.; Deyev, S. M.; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Деев, Сергей Михайлович