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Скрибицкий, Всеволод Андреевич

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

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Скрибицкий

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Всеволод Андреевич

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Теперь показываю 1 - 8 из 8

Только метаданные
Preparation of closo-Dodecaborate Anion Conjugate with Ethyl Glycinate and Study of Its Biodistribution in Melanoma Model B16F10
(2024) Ryabchikova, M. N.; Finogenova, Yu. A.; Skribitsky, V. A.; Shpakova, K. E.; Lipengolts, A. A.; Скрибицкий, Всеволод Андреевич; Липенгольц, Алексей Андреевич
Только метаданные
Substituted Derivative of the сloso-Dodecaborate Anion Based on para-Iodo-L-Phenylalanine as a Novel Compound for BNCT with CT Imaging Capability
(2024) Ryabchikova, M. N.; Nelyubin, A. V.; Skribitsky, V. A.; Lipengolts, A. A.; Скрибицкий, Всеволод Андреевич; Липенгольц, Алексей Андреевич
Только метаданные
Hafnium Complexes as Contrast Media and Dose Enhancing Agents for Radiology and Contrast-Enhanced Radiotherapy
(2024) Lipengolts, A. A.; Skribitsky, V. A.; Finogenova, Yu. A.; Shpakova, K. E.; Липенгольц, Алексей Андреевич; Скрибицкий, Всеволод Андреевич
Только метаданные
Transplanted Murine Tumours SPECT Imaging with 99mTc Delivered with an Artificial Recombinant Protein
(2024) Pozdniakova, N. V.; Lipengolts, A. A.; Skribitsky, V. A.; Shpakova, K. E.; Липенгольц, Алексей Андреевич; Скрибицкий, Всеволод Андреевич
Tc is a well-known radionuclide that is widely used and readily available for SPECT/CT (Single-Photon Emission Computed Tomography) diagnosis. However, commercial isotope carriers are not specific enough to tumours, rapidly clear from the bloodstream, and are not safe. To overcome these limitations, we suggest immunologically compatible recombinant proteins containing a combination of metal binding sites as
Только метаданные
Binary technologies of malignant tumors radiotherapy
(2021) Lipengolts, A. A.; Finogenova, Yu. A.; Skribitsky, V. A.; Grigorieva, E. Yu.; Липенгольц, Алексей Андреевич; Скрибицкий, Всеволод Андреевич
© 2021 Institute of Physics Publishing. All rights reserved.Binary radiotherapy (BRT) approach for curing malignant tumors is described in the paper. Two main modalities of BRT, i.e. Neutron Capture Therapy and Contrast Enhanced Radiotherapy are being described and compared. Physics of BRT practical implementation is discussed. Clinical efficacy of BRT in treating brain tumors and head and neck cancer as well as pharmacological challenges and achievements are being reviewed.
Только метаданные
In Vivo Studies of Laser-Ablated Gold Nanoparticles as Dose Enhancers for Binary Radiotherapy of Cancer
(2022) Skribitsky, V. A.; Finogenova, Yu. A.; Lipengolts, A. A.; Pozdniakova, N. V.; Smirnova, A. V.; Shpakova, K. E.; Grigorieva, E. Yu.; Скрибицкий, Всеволод Андреевич; Липенгольц, Алексей Андреевич
Только метаданные
A Spectrophotometric Method for Estimation of the Size and Concentration of Laser Ablated Gold Nanoparticles
(2022) Skribitsky, V. A.; Pozdniakova, N. V.; Lipengolts, A. A.; Popov, A. A.; Tikhonowski, G. V.; Finogenova, Y. A.; Smirnova, A. V.; Grigorieva, E. Y.; Скрибицкий, Всеволод Андреевич; Липенгольц, Алексей Андреевич; Попов, Антон Александрович; Тихоновский, Глеб Валерьевич
© 2022, Pleiades Publishing, Inc.Abstract—The ability to use a spectrophotometric method to estimate the size and concentration of gold nanoparticles obtained by the method of laser ablation was considered. Gold nanoparticles synthesized by different methods have different physical and chemical properties of their surface. This can affect their optical properties in a colloidal solution. The results obtained in this work confirm the ability to use the spectrophotometric method to estimate the size and concentration of nanoparticles obtained by the method of laser ablation. It was demonstrated that it is optimal to estimate the concentration of nanoparticles using the spectrophotometric method at a wavelength of 400 nm. The determination of the size of nanoparticles by the absorption spectra in the ultraviolet and visible regions is possible for particles with a size of at least 11 nm.
Только метаданные
Using ELP Repeats as a Scaffold for De Novo Construction of Gadolinium-Binding Domains within Multifunctional Recombinant Proteins for Targeted Delivery of Gadolinium to Tumour Cells
(2022) Pozdniakova, N. V.; Ryabaya, O. V.; Semkina, A. S.; Shevelev, A. B.; Skribitsky, V. A.; Скрибицкий, Всеволод Андреевич
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.Three artificial proteins that bind the gadolinium ion (Gd3+) with tumour-specific ligands were de novo engineered and tested as candidate drugs for binary radiotherapy (BRT) and contrast agents for magnetic resonance imaging (MRI). Gd3+-binding modules were derived from calmodulin. They were joined with elastin-like polypeptide (ELP) repeats from human elastin to form the fourcentre Gd3+-binding domain (4MBS-domain) that further was combined with F3 peptide (a ligand of nucleolin, a tumour marker) to form the F3-W4 block. The F3-W4 block was taken alone (E2-13W4 protein), as two repeats (E1-W8) and as three repeats (E1-W12). Each protein was supplemented with three copies of the RGD motif (a ligand of integrin αvβ3) and green fluorescent protein (GFP). In contrast to Magnevist (a Gd-containing contrast agent), the proteins exhibited three to four times higher accumulation in U87MG glioma and A375 melanoma cell lines than in normal fibroblasts. The proteins remained for >24 h in tumours induced by Ca755 adenocarcinoma in C57BL/6 mice. They exhibited stability towards blood proteases and only accumulated in the liver and kidney. The technological advantages of using the engineered proteins as a basis for developing efficient and non-toxic agents for early diagnosis of tumours by MRI as well as part of BRT were demonstrated.