Инновационные технологии ядерной медицины и лучевой диагностики и терапии

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Просмотр Инновационные технологии ядерной медицины и лучевой диагностики и терапии по Автор "Deyev, S."

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    HAFNIUM-BASED METAL ORGANIC FRAMEWORKS AS TARGETING DRUG DELIVERY SYSTEMS
    (НИЯУ МИФИ, 2024) Gamburg, E.; Griaznova, O.; Sogomonyan, A.; Mirkasymov, A.; Deyev, S.; Грязнова, Ольга Юрьевна
    Modern traditional medications are proved to have several disadvantages such as low solubility, broad distribution and high toxicity to heathy tissues [1]. However, these problems can be solved by a class of nano-sized particles which, in recent days, has been widely developed to alleviate these problems by means of controlled drug release and targeted delivery [2].
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    RADIOSENSITIZATION EFFECT OF BISMUTH-BASED NANOSHEETS UNDER PROTON BEAM IRRADIATION
    (НИЯУ МИФИ, 2024) Kolmanovich, D.; Popov, A.; Zelepukin, I.; Shemyakov, A.; Savintseva, I.; Kotelnikova, A.; Chukavin, N.; Pivovarov, N.; Deyev, S.; Kabashin, A.; Zavestovskaya, I.; Завестовская, Ирина Николаевна
    Radiation therapy is used as the first line of therapy in more than 50% of patients with malignant tumors [1]. However, this therapeutic approach still has difficulties in effectively delivering the dose directly to the tumor growth zone. The transition to proton therapy of the tumor makes it possible to increase the accuracy of dose unloading, since the main proton energy is released in the biological tissue at the end of the particle trajectory ("Bragg peak") in accordance with the profile of the deep dose [2]. Despite the numerous known benefits of proton beam therapy, it has certain limitations of effectiveness due to the low therapeutic yield. One of the most promising methods of promoting proton therapy is associated with the use of nanotechnology approaches, which involve the use of nanoparticles as sensitizers for improved results caused by radiotherapy. Nanoparticles containing elements with high electron density (high Z element), such as bismuth, can act as such a radio sensitizer.