Publication: Phosphorus (31P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive Ph. A study involving 23 volunteers. part i
Дата
2019
Авторы
Pronin, I. N.
Zakharova, N. E.
Podoprigora, A. E.
Batalov, A. I.
Postnov, A. A.
Journal Title
Journal ISSN
Volume Title
Издатель
Аннотация
© 2019, Media Sphera Publishing Group. All rights reserved.Evaluation of brain metabolism is an important part in examination of brain lesions. Phosphorus magnetic resonance spectroscopy opens up great opportunities for studying the energy metabolism and allows noninvasive examination of metabolic processes occurring both in healthy and in pathologic brain tissue by obtaining a spectrum of phosphorus-containing metabolites involved in the turnover of cell membrane phospholipids. The technique presented in this paper was used to conduct31P MR spectroscopy and to estimate the ratio between the peaks of the main metabolites and intracellular pH of the healthy brain tissue of 23 volunteers in the age group under 30 years old in clinical settings. Based on the recorded stable phosphorus spectra of metabolites of the healthy brain tissue, the value of intracellular pH (6.963±0.044) and the ratio of the main PME/PDE peaks (1.17±0.20) were calculated. The database was created to subsequently analyze the metabolic changes in brain tissue spectra in norm and in pathology, as well as the intracellular pH variations that have diagnostic and prognostic value.
Описание
Ключевые слова
Цитирование
Phosphorus (31P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive Ph. A study involving 23 volunteers. part i / Pronin, I.N. [et al.] // Zhurnal Voprosy Nejrokhirurgii Imeni N.N. Burdenko. - 2019. - 83. - № 2. - P. 5-10. - 10.17116/neiro2019830215