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Phosphorus (31P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive Ph. A study involving 23 volunteers. part i

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dc.contributor.authorPronin, I. N.
dc.contributor.authorZakharova, N. E.
dc.contributor.authorPodoprigora, A. E.
dc.contributor.authorBatalov, A. I.
dc.contributor.authorPostnov, A. A.
dc.date.accessioned2024-11-21T09:25:38Z
dc.date.available2024-11-21T09:25:38Z
dc.date.issued2019
dc.description.abstract© 2019, Media Sphera Publishing Group. All rights reserved.Evaluation of brain metabolism is an important part in examination of brain lesions. Phosphorus magnetic resonance spectroscopy opens up great opportunities for studying the energy metabolism and allows noninvasive examination of metabolic processes occurring both in healthy and in pathologic brain tissue by obtaining a spectrum of phosphorus-containing metabolites involved in the turnover of cell membrane phospholipids. The technique presented in this paper was used to conduct31P MR spectroscopy and to estimate the ratio between the peaks of the main metabolites and intracellular pH of the healthy brain tissue of 23 volunteers in the age group under 30 years old in clinical settings. Based on the recorded stable phosphorus spectra of metabolites of the healthy brain tissue, the value of intracellular pH (6.963±0.044) and the ratio of the main PME/PDE peaks (1.17±0.20) were calculated. The database was created to subsequently analyze the metabolic changes in brain tissue spectra in norm and in pathology, as well as the intracellular pH variations that have diagnostic and prognostic value.
dc.format.extentС. 5-10
dc.identifier.citationPhosphorus (31P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive Ph. A study involving 23 volunteers. part i / Pronin, I.N. [et al.] // Zhurnal Voprosy Nejrokhirurgii Imeni N.N. Burdenko. - 2019. - 83. - № 2. - P. 5-10. - 10.17116/neiro2019830215
dc.identifier.doi10.17116/neiro2019830215
dc.identifier.urihttps://www.doi.org/10.17116/neiro2019830215
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85067098311&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/18218
dc.relation.ispartofZhurnal Voprosy Nejrokhirurgii Imeni N.N. Burdenko
dc.titlePhosphorus (31P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive Ph. A study involving 23 volunteers. part i
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume83
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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