Publication: fmri and tractographic studies of cognitive systems in the human brain at the norm and the paranoid schizophrenia
Дата
2019
Авторы
Orlov, V. A.
Malakhov, D. G.
Maslennikova, A. V.
Arkhipov, A. Y.
Ushakov, V. L.
Kartashov, S. I.
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© Springer Nature Switzerland AG 2019. This study is aimed at a systematic study of the work of neural networks of the human brain and their architecture in norm and in schizophrenia. To obtain the neurophysiological data, a unique complex of experimental equipment for world-class neurocognitive studies was used. The data obtained showed a significant decrease in the structural connectivity relationships for the rich club coefficient for a group of schizophrenic patients compared with the norm. Perception of emotionally negative visual and audio stimuli related to delusions in patients with schizophrenia does not lead to a significant decrease in BOLD signal as compared with the norm in Calcarine_L, Cerebelum_4_5_R, ParaHippocampal_LR, Precuneus_L, Temporal_Sup_R areas. The differences found in the structural and functional patterns of cognitive-affective disorders can serve as prognostic biomarkers in patients with schizophrenia and will make a significant contribution to the development of high-tech diagnostics in the early stages of mental illness.
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fmri and tractographic studies of cognitive systems in the human brain at the norm and the paranoid schizophrenia / Orlov,V.A. [et al.] // Studies in Computational Intelligence. - 2019. - 799. - P. 291-299. - 10.1007/978-3-030-01328-8_35