Publication:
Impact of nanocapsules on red blood cells interplay jointly assessed by optical tweezers and microscopy

Файлы
W2996658875.pdf(6.81 MB)
Дата
2020
Авторы
Avsievich, T.
Tarakanchikova, Y.
Zhu, R.
Popov, A.
Meglinski, I.
Journal Title
Journal ISSN
Volume Title
Издатель
Научные группы
Организационные подразделения
OrgUnit Logo
Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
Выпуск журнала
Аннотация
© 2019 The Author(s).In the framework of novel medical paradigm the red blood cells (RBCs) have a great potential to be used as drug delivery carriers. This approach requires an ultimate understanding of the peculiarities of mutual interaction of RBC influenced by nano-materials composed the drugs. Optical tweezers (OT) is widely used to explore mechanisms of cells' interaction with the ability to trap non-invasively, manipulate and displace living cells with a notably high accuracy. In the current study, the mutual interaction of RBC with polymeric nano-capsules (NCs) is investigated utilizing a two-channel OT system. The obtained results suggest that, in the presence of NCs, the RBC aggregation in plasma satisfies the 'cross-bridges' model. Complementarily, the allocation of NCs on the RBC membrane was observed by scanning electron microscopy (SEM), while for assessment of NCs-induced morphological changes the tests with the human mesenchymal stem cells (hMSC) was performed. The combined application of OT and advanced microscopy approaches brings new insights into the conception of direct observation of cells interaction influenced by NCs for the estimation of possible cytotoxic effects.
Описание
Ключевые слова
Цитирование
Impact of nanocapsules on red blood cells interplay jointly assessed by optical tweezers and microscopy / Avsievich, T. [et al.] // Micromachines. - 2020. - 11. - № 1. - 10.3390/mi11010019
URI
https://www.doi.org/10.3390/mi11010019
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85079507394&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000514309100019
 https://openrepository.mephi.ru/handle/123456789/20311
Коллекции
Публикации