Publication:
Multifunctional nitrogen-doped carbon dots for HS- sensing and mitochondrial-targeted imaging

Дата
2022
Авторы
Cai, H.
Liu, A.
Zhang, M.
Song, J.
Qu, J.
Journal Title
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Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
Выпуск журнала
Аннотация
© 2022 Elsevier B.V.Hydrogen sulfide ions (HS-) are an important endogenous ion species found in the human body, with HS- concentration changes known to play an important role in regulating various physiological activities. This study describes a simple strategy for preparing N-doped carbon dots (NCDs) using hydrothermal synthesis that utilize 3-aminophenol and tartaric acid. Aqueous solutions of these NCDs produced a green fluorescence under excitation at 494 nm and demonstrated good photostability under different NaCl concentrations, pH values and UV irradiation time. Moreover, the NCDs as probe also showed high sensitivity and selectivity for detecting HS-. Additionally, these NCDs exhibit excellent biocompatibility and low cytotoxicity making them ideal for cell-based imaging and colocalization experiments that was further verified the ability of these NCDs to cross the cell membrane and label the mitochondria. More importantly, we can successfully realize the detection and visualization of exogenous HS- in mitochondria. Thus, these NCDs-based probe can reasonably be expected to replace common commercial probe especially in the organelle imaging and fluorescent visualization of the mitochondria.
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Цитирование
Multifunctional nitrogen-doped carbon dots for HS- sensing and mitochondrial-targeted imaging / Cai, H. [et al.] // Sensors and Actuators B: Chemical. - 2022. - 367. - 10.1016/j.snb.2022.132048
URI
https://www.doi.org/10.1016/j.snb.2022.132048
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85130519459&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000807805200001
 https://openrepository.mephi.ru/handle/123456789/27935
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