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Smart electrospun hybrid nanofibers functionalized with ligand-free titanium nitride (Tin) nanoparticles for tissue engineering

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dc.contributor.authorNirwan, V. P.
dc.contributor.authorFilova, E.
dc.contributor.authorAl-Kattan, A.
dc.contributor.authorFahmi, A.
dc.contributor.authorKabashin, A. V.
dc.contributor.authorКабашин, Андрей Викторович
dc.date.accessioned2024-11-29T12:07:15Z
dc.date.available2024-11-29T12:07:15Z
dc.date.issued2021
dc.description.abstract© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Herein, we report the fabrication and characterization of novel polycaprolactone (PCL)-based nanofibers functionalized with bare (ligand-free) titanium nitride (TiN) nanoparticles (NPs) for tissue engineering applications. Nanofibers were prepared by a newly developed protocol based on the electrospinning of PCL solutions together with TiN NPs synthesized by femtosecond laser ablation in acetone. The generated hybrid nanofibers were characterised using spectroscopy, mi-croscopy, and thermal analysis techniques. As shown by scanning electron microscopy measure-ments, the fabricated electrospun nanofibers had uniform morphology, while their diameter varied between 0.403 ± 0.230 µm and 1.1 ± 0.15 µm by optimising electrospinning solutions and parameters. Thermal analysis measurements demonstrated that the inclusion of TiN NPs in nanofibers led to slight variation in mass degradation initiation and phase change behaviour (Tm). In vitro viability tests using the incubation of 3T3 fibroblast cells in a nanofiber-based matrix did not reveal any ad-verse effects, confirming the biocompatibility of hybrid nanofiber structures. The generated hybrid nanofibers functionalized with plasmonic TiN NPs are promising for the development of smart scaffold for tissue engineering platforms and open up new avenues for theranostic applications.
dc.format.extentС. 1-17
dc.identifier.citationSmart electrospun hybrid nanofibers functionalized with ligand-free titanium nitride (Tin) nanoparticles for tissue engineering / Nirwan, V.P. [et al.] // Nanomaterials. - 2021. - 11. - № 2. - P. 1-17. - 10.3390/nano11020519
dc.identifier.doi10.3390/nano11020519
dc.identifier.urihttps://www.doi.org/10.3390/nano11020519
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85101477038&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/23742
dc.relation.ispartofNanomaterials
dc.titleSmart electrospun hybrid nanofibers functionalized with ligand-free titanium nitride (Tin) nanoparticles for tissue engineering
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume11
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relation.isAuthorOfPublication.latestForDiscoveryb79a080b-900d-4655-ba2e-53fd552b3a15
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
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