Publication: A Comparative Study of the Pharmacokinetics of Bis- and Pentaphosphonic Acids Labeled with Gallium-68 in Rats with Experimental Model of Bone Callus
Дата
2020
Авторы
Kuzenkova, K. A.
Shegai, P. V.
Ivanov, S. A.
Kaprin, A. D.
Tishchenko, V. K.
Petriev, V. M.
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Аннотация
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.We analyzed biodistribution of 68Ga-labeled hydroxyethylidenediphosphonic acid (68Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (68Ga-DTPMP) in Wistar rats with experimental model of bone callus. It was shown that the content of 68Ga-DTPMP and 68Ga-HEDP in bone callus was ~1.5-fold higher than in intact femur. 68Ga-DTPMP was characterized by higher stability in vivo, higher uptake in the bone tissue, and lower uptake in others visceral organs in comparison with 68Ga-HEDP. Thus, 68Ga-DTPMP had more suitable pharmacokinetic properties than 68Ga-HEDP.
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A Comparative Study of the Pharmacokinetics of Bis- and Pentaphosphonic Acids Labeled with Gallium-68 in Rats with Experimental Model of Bone Callus / Kuzenkova, K.A. [et al.] // Bulletin of Experimental Biology and Medicine. - 2020. - 10.1007/s10517-020-04945-z
URI
https://www.doi.org/10.1007/s10517-020-04945-z
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https://openrepository.mephi.ru/handle/123456789/22388
https://www.scopus.com/record/display.uri?eid=2-s2.0-85091687558&origin=resultslist
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000573428600008
https://openrepository.mephi.ru/handle/123456789/22388