Publication: The influence of temperature on biodistribution of N,N,N',N'-ethylenediaminetetrakis(methylene phosphonic) acid labeled with gallium-68
Дата
2021
Авторы
Tishchenko, V. K.
Stepchenkova, E. D.
Shegai, P. V.
Ivanov, S. A.
Petriev, V. M.
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© 2021 Institute of Physics Publishing. All rights reserved.Bone metastases are serious complication in the progression of various types of cancer. It determines the requirement of modern nuclear diagnostic tools, including positron emission tomography (PET). In this study the biodistribution of EDTMP labeled with gallium-68 (68Ga-EDTMP) prepared at different temperature (20, 50, and 95 oC) was investigated. All experimental studies were performed in healthy intact Wistar rats by measuring the radioactivity in organs and tissues with gamma counter. All 68Ga-EDTMP formulations accumulated predominantly in bones. Only in tibia the uptake of 68Ga-EDTMP prepared at 95 oC was higher (p < 0.05) than 68Ga-EDTMP prepared at 20 oC, but in other bones there weren't any statistical differences in uptake of 68Ga-EDTMP formulations. The amounts of 68Ga-EDTMP formulations in soft organs and tissues were lower when compared with bones. In conclusion, a temperature of reaction mixture had an influence on the biodistribution of 68Ga-EDTMP in bones.
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The influence of temperature on biodistribution of N,N,N',N'-ethylenediaminetetrakis(methylene phosphonic) acid labeled with gallium-68 / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2021. - 2058. - № 1. - 10.1088/1742-6596/2058/1/012042