Publication:
Compartmental Modeling of the Kinetics of 188Re-Labeled Pentaphosphonic Acid in Rats with Bone Callus

Дата
2022
Авторы
Matveev, A. V.
Tishchenko, V. K.
Petriev, V. M.
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Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Аннотация
© 2022, Springer Science+Business Media, LLC, part of Springer Nature.Phosphonic acids labeled with rhenium-188 (188Re) are promising bone-seeking radiopharmaceuticals (RPs) for bone metastases therapy. The present work was aimed to develop a compartmental mathematical model of 188Re-pentaphosphonic acid (188Re-PPA) kinetics and calculate its pharmacokinetic transport parameters in healthy experimental animals and animals with bone pathology. The developed compartmental model of drug kinetics proposed two approaches to identify the transport constants that were based on the residual functional and an approximation of monoexponential functions. It was found that the presence of bone callosity significantly affected the biodistribution of 188Re-PPA in organs and tissues. The transport constants of excretion for all bone tissues in rats with a femoral callus were 10 times lower and the biological half-life was 5 times higher than in healthy rats. The highest activities were registered in bones, bone callus, kidneys, and liver. Results of the compartmental modeling and mathematical calculations of the pharmacokinetic parameters confirmed quantitatively significant changes in the biodistribution of the studied RP in rats with bone pathology as compared to healthy rats.
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Цитирование
Matveev, A. V. Compartmental Modeling of the Kinetics of 188Re-Labeled Pentaphosphonic Acid in Rats with Bone Callus / Matveev, A.V., Tishchenko, V.K., Petriev, V.M. // Pharmaceutical Chemistry Journal. - 2022. - 55. - № 10. - P. 999-1005. - 10.1007/s11094-021-02528-4
URI
https://www.doi.org/10.1007/s11094-021-02528-4
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85124368573&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000749961000004
 https://openrepository.mephi.ru/handle/123456789/28745
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