Персона:
Попов, Антон Александрович

Научные группы

Научная группа

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

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Попов

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Антон Александрович

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Только метаданные
Comparison of pharmacokinetics and biodistribution of laser-synthesized plasmonic Au and TiN nanoparticles
(2021) Tselikov, G. I.; Al-Kattan, A.; Bailly, A. -L.; Correard, F.; Popov, A. A.; Zelepukin, I. V.; Tikhonowski, G. V.; Popova-Kuznetsova, E. A.; Klimentov, S. M.; Deyev, S. M.; Kabashin, A. V.; Попов, Антон Александрович; Тихоновский, Глеб Валерьевич; Попова-Кузнецова, Елена Алефтиновна; Климентов, Сергей Михайлович; Деев, Сергей Михайлович; Кабашин, Андрей Викторович
© 2021 Institute of Physics Publishing. All rights reserved.Plasmonic nanostructures offer wide range of diagnostic and therapeutic functionalities for biomedical applications. Gold nanoparticles (Au NPs) present one of the most explored nanomaterial in this field, while titanium nitride nanoparticles (TiN NPs) is a new promising nanomaterial with superior plasmonic properties for biomedicine. However conventional chemical techniques for the synthesis of these nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synthesized Au and TiN NPs offer exceptional purity (no contamination by by-products or ligands) and unusual surface chemistry. Therefore, these NPs present a viable alternative to chemically synthesized counterparts. This work presents comparative analysis of pharmacokinetics and biodistribution of laser-synthesized 20 nm Au and TiN NPs under intravenous administration in mice model. Our data show that Au NPs and bare TiN NPs are rapidly eliminated from the blood circulation and accumulate preferentially in liver and spleen, while coating of TiN NPs by hydrophilic polymer polyethylene glycol (PEG) significantly prolongates blood circulation time and improves delivery of the NPs to tumor. We finally discuss potential applications of laser synthesized Au NPs in SERS, SEIRA and electrocatalysis, while TiN nanoparticles are considered as promising agents for photothermal therapy and photoacoustic imaging.
Только метаданные
Laser-ablative synthesis of stable size-tunable Bi nanoparticles and their functionalization for radiotherapy applications
(2021) Tikhonowski, G. V.; Popov, A. A.; Popova-Kuznetsova, E. A.; Klimentov, S. M.; Prasad, P. N.; Kabashin, A. V.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Попова-Кузнецова, Елена Алефтиновна; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович
© 2021 Institute of Physics Publishing. All rights reserved.Nanoformulations of high-Z elements can improve therapeutic outcome in radiotherapy-based treatment of tumors, but current nanomedicine implementations in radiotherapy still need biocompatible, non-toxic nano-agents exhibiting low polydispersity and high colloidal stability. Here, we elaborate methods of femtosecond (fs) laser ablation in water and organic solvents to fabricate stable aqueous colloidal solutions of ultrapure elemental Bi nanoparticles (NPs) and characterize them. We show that fs laser ablation of Bi target leads to the formation of spherical elemental Bi NPs having 25 nm mean size and wide size-dispersion. NPs prepared in water undergo fast conversion into 400-500 nm flake-like nanosheets, while NPs prepared in acetone demonstrate a high colloidal stability. We then employ methods of fs laser fragmentation to control mean size and size dispersion of Bi NPs. Stable aqueous solution of Bi NPs suitable for biomedical applications can be obtained by coating with Pluronic® F-127. We finally show that surface modification of Bi NPs increases its colloidal stability in phosphate buffer saline (PBS) solution by more than 6 fold. Exempt of any toxic synthetic by-products, laser-ablated Bi NPs present a novel appealing nanoplatform for image-guided combination photo- and radiotherapy.
Только метаданные
Evolution of the properties of nanomaterials obtained by pulsed laser ablation
(2021) Faizullayeva, S.; Klimentov, S. M.; Popov, A. A.; Файзуллаева, Сабина Юсуповна; Климентов, Сергей Михайлович; Попов, Антон Александрович
The synthesis and application of metal and ceramic nanoparticle are significant subject in science and engineering. The metal nanoparticles such as gold, silver, and copper nanoparticles have more application in material science, nanomedicine, electronic, photonic, and art. One of the green methods for preparation of metal nanoparticles is laser ablation technique that offers a unique tool for nanofabrication of nanoparticles. In this work, gold colloids were prepared by pulsed laser ablation of high purity gold plate immersed in deionized water and 10µM NaCl solution. After ablation process, we study the change in the size distribution of nanoparticles after the ablation process for a month. © 2021 Institute of Physics Publishing. All rights reserved.
Только метаданные
Transition metal dichalcogenide nanospheres for high-refractive-index nanophotonics and biomedical theranostics
(2022) Tselikov, G. I.; Ermolaev, G. A.; Popov, A. A.; Tikhonowski, G. V.; Klimentov, S. M.; Попов, Антон Александрович; Тихоновский, Глеб Валерьевич; Климентов, Сергей Михайлович
Recent developments in the area of resonant dielectric nanostructures have created attractive opportunities for concentrating and manipulating light at the nanoscale and the establishment of the new exciting field of all-dielectric nanophotonics. Transition metal dichalcogenides (TMDCs) with nanopatterned surfaces are especially promising for these tasks. Still, the fabrication of these structures requires sophisticated lithographic processes, drastically complicating application prospects. To bridge this gap and broaden the application scope of TMDC nanomaterials, we report here femtosecond laser-ablative fabrication of water-dispersed spherical TMDC (MoS 2 and WS 2 ) nanoparticles (NPs) of variable size (5 to 250 nm). Such NPs demonstrate exciting optical and electronic properties inherited from TMDC crystals, due to preserved crystalline structure, which offers a unique combination of pronounced excitonic response and high refractive index value, making possible a strong concentration of electromagnetic field in the NPs. Furthermore, such NPs offer additional tunability due to hybridization between the Mie and excitonic resonances. Such properties bring to life a number of nontrivial effects, including enhanced photoabsorption and photothermal conversion. As an illustration, we demonstrate that the NPs exhibit a very strong photothermal response, much exceeding that of conventional dielectric nanoresonators based on Si. Being in a mobile colloidal state and exhibiting superior optical properties compared to other dielectric resonant structures, the synthesized TMDC NPs offer opportunities for the development of next-generation nanophotonic and nanotheranostic platforms, including photothermal therapy and multimodal bioimaging.
Только метаданные
Laser Synthesis of Bismuth Nanoparticles for Multimodal Theranostics of Oncological Diseases
(2022) Tikhonowski, G. V.; Popov, A. A.; Kurinnaya, A. A.; Garmash, A. A.; Gromushkina, E. V.; Zavestovskaya, I. N.; Klimentov, S. M.; Klimentov, S.M.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Гармаш, Александр Александрович; Громушкина, Елена Вячеславовна; Климентов, Сергей Михайлович
Abstract: The effect of laser radiation parameters on properties of bismuth (Bi) nanoparticles (NPs) produced by pulsed laser ablation in liquids (PLAL) was studied. We demonstrated that the average NPs size increases under the increase of laser radiation energy and the decrease in the distance from the focusing lens to the target surface. The obtained results provide a tool for a controllable synthesis of new functional nanomaterials for biomedical applications. © 2022, Allerton Press, Inc.
Только метаданные
Modeling of Nanoparticles Formation Process due to Pulsed Laser Ablation in Liquids
(2022) Ivanov, D. S.; Klimentov, S. M.; Popov, A.; Shahov, P.; Kabashin, A. V.; Иванов, Дмитрий Сергеевич; Климентов, Сергей Михайлович; Попов, Антон Александрович; Шахов, Павел Владимирович; Кабашин, Андрей Викторович
Только метаданные
Study of IR Photoheating of Aqueous Solutions of Boron Nanoparticles Synthesized by Pulsed Laser Ablation for Cancer Therapy
(2022) Belyaev, I. B.; Zelepukin, I. V.; Pastukhov, A. I.; Shakhov, P. V.; Tikhonowski, G. V.; Popov, A. A.; Zakharkiv, A. Y.; Klimentov, S. M.; Garmash, A. A.; Zavestovskaya, I. N.; Deyev, S. M.; Kabashin, A. V.; Шахов, Павел Владимирович; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Захаркив, Анастасия Юрьевна; Климентов, Сергей Михайлович; Гармаш, Александр Александрович; Завестовская, Ирина Николаевна; Деев, Сергей Михайлович
Abstract: Photothermal properties of boron (B) nanoparticles (NPs) synthesized by pulsed laser ablation in liquid (PLAL) are studied. It is found that B NPs have high optical extinction coefficient in the near infrared (IR) region, in particular, its value was 0.2 l/(cm g) at a wavelength of 800 nm. It is shown that aqueous suspensions of B NPs can be heated during laser irradiation with a wavelength of 830 nm and a radiation power of 1 W. Here, the temperature increase varied from 6.5 to 36°C under the increase of the particle concentration from 0.04 to 0.8 g/L; while the relevant parameter in the absence of particles was 2°C. B NPs were able to provide a stable photothermal response during several irradiation cycles. The results evidence a high potential of B NPs as sensitizers of photothermal therapy (PTT). © 2022, Allerton Press, Inc.
Только метаданные
Plasmonically enhanced two-photon absorption induced photoacoustic microscopy with laser-synthesized TiN nanoparticles
(2022) Das, A.; Pereira, A. C. M. V.; Popov, A. A.; Klimentov, S. M.; Gomes, A. S. L.; Попов, Антон Александрович; Климентов, Сергей Михайлович
Combining photonic excitation and acoustic detection, photoacoustic imaging (PAI) presents one of the most promising noninvasive biomedical diagnostic modalities, but this technique still lacks efficient nano-sized contrast agents absorbing light in the region of relative tissue transparency (630вЂ“900 nm). Here, we explore the use of titanium nitride (TiN) nanoparticles (NPs) fabricated by methods of pulsed laser ablation in liquids as a contrast agent in PAI. When prepared in acetone, the NPs are spherical, have an average size of 25 nm, and exhibit a broad plasmonic absorption peak around 700 nm. We show that solutions of these NPs render possible a strong nonlinear photoacoustic response and the generation of photoacoustic images with 67 Ојm resolution within the biological transparency window. The observed effect is explained by a plasmonically enhanced two-photon absorption process in TiN NPs. Combined with earlier demonstrated capability of generating photothermal therapeutic effect, relative chemical purity, and excellent biocompatibility, laser-synthesized TiN NPs promise attractive applications in biomedical theranostics involving imaging modalities based on photoacoustics microscopy or tomography.
Только метаданные
Laser-ablative aqueous synthesis and characterization of elemental boron nanoparticles for biomedical applications
(2022) Pastukhov, A. I.; Belyaev, I. B.; Bulmahn, J. C.; Zelepukin, I. V.; Popov, A. A.; Zavestovskaya, I. N.; Klimentov, S. M.; Deyev, S. M.; Prasad, P. N.; Kabashin, A. V.; Попов, Антон Александрович; Завестовская, Ирина Николаевна; Климентов, Сергей Михайлович; Деев, Сергей Михайлович
Только метаданные
Investigation of the Distribution of Magnetic Nanoparticles in Tumor Tissues by the Method of Scanning Magnetic Force Nanotomography
(2022) Agapova, O. I.; Efimov, A. E.; Mochalov, K. E.; Solovyeva, D. O.; Klimentov, S. M.; Popov, A. A.; Oleinikov, V. A.; Климентов, Сергей Михайлович; Попов, Антон Александрович; Олейников, Владимир Александрович
© 2022, Pleiades Publishing, Ltd.Abstract: The development of effective biomedical technologies using magnetic nanoparticles (MNPs) for the tasks of oncotherapy and nanodiagnostics requires the development and implementation of new methods for the analysis of micro- and nanoscale distributions of MNPs in the volume of cells and tissues. The paper presents a new approach to three-dimensional analysis of MNP distributions - scanning magnetic force nanotomography as applied to the study of tumor tissues. Correlative reconstruction of MNP distributions and nanostructure features of the studied tissues made it possible to quantitatively estimate the parameters of three-dimensional distributions of composite nanoparticles based on silicon and iron oxide obtained by femtosecond laser ablation and injected intravenously and intratumorally into tumor tissue samples of B16/F1 mouse melanoma. The developed technology based on the principles of scanning probe nanotomography is applicable for studying the features of three-dimensional micro- and nanoscale distributions of magnetic nanoparticles in biomaterials, cells and tissues of various types.