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Шалтаева, Юлия Ринатовна

Организационные подразделения

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Институт нанотехнологий в электронике, спинтронике и фотонике

Институт ИНТЭЛ занимается научной деятельностью и подготовкой специалистов в области исследования физических принципов, проектирования и разработки технологий создания компонентной базы электроники гражданского и специального назначения, а также построения современных приборов на её основе. Наша основная цель – это создание и развитие научно-образовательного центра мирового уровня в области наноструктурных материалов и устройств электроники, спинтроники, фотоники, а также создание эффективной инновационной среды в области СВЧ-электронной и радиационно-стойкой компонентной базы, источников ТГц излучения, ионно-кластерных технологий материалов.

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Шалтаева

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Юлия Ринатовна

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Ion mobility spectrometry of N-methylimidazole and possibilities of its determination
(2021) Aleksandrova, D. A.; Melamed, T. B.; Baberkina, E. P.; Fenin, A. A.; Shaltaeva, Y. R.; Belyakov, V. V.; Шалтаева, Юлия Ринатовна; Беляков, Владимир Васильевич
© D.A. Aleksandrova, T.B. Melamed, E.P. Baberkina, A.A. Fenin, E.S. Osinova, A.E. Kovalenko, R.V. Yakushin, Yu.R. Shaltaeva, V.V. Belyakov, D.I. Zykova, 2021.Objectives. To determine the ion mobility of N-methylimidazole, establish the structure of ions corresponding to characteristic signals, and determine the detection limit of N-methylimidazole on the ion-drift detector Kerber. Methods. Ion mobility spectrometry was used to study the ionization processes. The enthalpies of the reactions of monomer and dimer ions were calculated in the ORCA 4.1.1 software by the B3LYP density functional method with a set of basic functions 6-31G (d, p). Results. The drift time and ion mobility values of N-methylimidazole were determined. A method for mathematical processing of spectra and a program for its implementation was developed. The changing peculiarities of the ion mobility spectrum during measurement at a given time were studied. According to the interpretation of the spectrum signals, the structure of the generated ions was proposed, and the enthalpies of ion formation were determined. Conclusions. The characteristic signal of the N-methylimidazole ion protonated at the nitrogen atom of the pyridine type was revealed. It was found that two signals in the ion mobility spectra of N-methylimidazole correspond to the presence of the monomer and dimer ions. The detection limit of N-methylimidazole on the ion-drift detector Kerber was determined, amounting to 3 pg.
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Perspective of use of shungite cathode for microbial fuel cell design
(2019) Parhaeva, A. P.; Bulycheva, E. S.; Kadochnikov, D. I.; Kulieva, M. A.; Losevskaya, E. G.; Sharapova, O. E.; Shuvalova, E. A.; Maslovskaya, E. V.; Sosin, D. V.; Shaltaeva, Y. R.; Sultanov, A. O.; Siglovaya, N. V.; Shostachenko, S. A.; Масловская, Елена Владимировна; Сосин, Дмитрий Витальевич; Шалтаева, Юлия Ринатовна; Султанов, Азрет Оюсович; Сигловая, Наталия Владимировна
© 2019 Published under licence by IOP Publishing Ltd. The article is devoted to one of the directions of alternative energy - the creation and use of microbial fuel cell (MFC). It is used anode made of plate of macro porous silicon doped with antimony. The cathode is a plate of shungite rock. Shungite is a natural stone containing fullerenes. The possibility of functioning and effective operation of this system is investigated.
Только метаданные
The review of bipolar ion mobility spectrometers
(2020) Shaltaeva, Y. R.; Golovin, A. V.; Vasilyev, V. K.; Gromov, E. A.; Matusko, M. A.; Malkin, E. K.; Ivanov, I. A.; Belyakov, V. V.; Pershenkov, V. S.; Шалтаева, Юлия Ринатовна; Малкин, Евгений Константинович; Иванов, Игорь Александрович; Беляков, Владимир Васильевич
© Springer Nature Switzerland AG 2020.The review considers the design of ion mobility spectrometers, which allow for the conditionally simultaneous detection of both positive and negative ions. The review of existing serial ion mobility spectrometers with simultaneous detection of substances in both spectrometric modes is carried out. The ways of realization of the bipolar ion mobility spectrometer are analyzed.
Только метаданные
Features of ion mobility spectrometry hardware-software complex
(2019) Shaltaeva, Y. R.; Gromov, E. A.; Belyakov, V. V.; Golovin, A. V.; Vasilyev, V. K.; Malkin, E. K.; Matusko, M. A.; Ivanov, I. I.; Шалтаева, Юлия Ринатовна; Беляков, Владимир Васильевич; Малкин, Евгений Константинович
© Published under licence by IOP Publishing Ltd. The ion mobility spectrometer (IMS) is a complex hardware and software device for gaseous analysis. The article describes bipolar IMS control system. The paper lists the main requirements in electronic units, the modes of their operation, the ranges of normal operation and the algorithm for handling emergency situations. The main electronics include: a unit for collecting and processing spectrometric data, an ion source control unit, a gate control unit, high-voltage generators, an ion mobility spectrometer control and synchronization system. The structure of additional electronics includes: control unit of actuating devices, air conditioning system, self-diagnostics and protection system. This article may be useful to designers of complex electronic analytical systems.
Только метаданные
Exhaled breath analysis in diagnosis of chronic heart failure with reduced left ventricular ejection fraction
(2019) Bykova, A. A.; Malinovskaya, L. K.; Trushina, O. V.; Chomakhidze, P. S.; Shaltaeva, Y. R.; Шалтаева, Юлия Ринатовна
© 2019, Media Sfera. All rights reserved.Objective — searching for chronic heart failure (CHF) biomarkers in patients with heart failure and reduced LVEF through exhaled breath analysis by proton mass spectrometry. Material and methods. The study included 42 patients with CHF and reduced LVEF (HF-REF) and 24 patients without CHF in the control group for the period from October 2014 to April 2016. Exhaled breath samples were collected in 1L Tedlar bags (USA). Exhaled breath samples were analyzed using PTR-MS (Compact PTR-MS, «Ionicon», Austria) within 24 hours after sampling. Results. Men significantly prevailed (90.5%) in HF group compared with the control group (59.3%; p<0.0001). Previous myocardial infarction was more common in patients with CHF (p=0.021). Exhaled breath composition in patients with CHF along 36 channels of mass spectrometer differs from that in the control group. Most of these substances (n=23) were in trace amounts in exhaled breath (<1 · 10–9). Pathophysiological mechanisms of formation are known only for acetone (985 · 10–9 vs. 330 · 10–9 in patients with HF and in the control group, respectively; p<0.0001). There were correlations of exhaled acetone with LVEF, mean pulmonary artery pressure, NT-proBNP, urea, uric acid and total bilirubin. It was also found that exhaled acetone concentrations are various in patients with different NYHA functional class of CHF and higher in patients with NYHA class IV compared with patients with NYHA class II (p=0.006). ROC-analysis was performed to estimate diagnostic accuracy of exhaled acetone for diagnosis of HF-REF. AUC was 0.811 (95% CI 0.707—0.915; p<0.0001). No correlation of exhaled acetone and blood glucose was revealed. Conclusion. Exhaled breath analysis may be used as a new non-invasive screening test for HF-REF. Exhaled acetone is characterized by the greatest diagnostic value.
Открытый доступ
Using of bioinformatic software methods for determining PAM sequences by analyzing of CRISPR sites
(2020) Sosin, D.; Maslovskaya, E.; Frolov, A.; Pavlenko, I.; Zhadaev, V.; Lebedev, M.; Leonov, Y.; Ivashchenko, N.; Sapozhnikova, V.; Shaltaeva, Y.; Масловская, Елена Владимировна; Павленко, Иван Александрович; Шалтаева, Юлия Ринатовна
© 2020 The Authors. Published by Elsevier B.V.Currently, CRISPR/Cas technology is one of the most actively developing in molecular biology as an instrument for genomic DNA editing and controlling gene activity at various levels. For today this technology has a number of limitations that makes it difficult to use. One of the main limitation is the conditions under which the Cas type proteins or their analogues cut DNA: 1) the complementary between sequence of protospacer and guiding RNA; 2)the special sequences flanking this protospacer on one or both ends. This special sequences usually unique for each enzyme and named PAM sites. However, if the ability to change guiding RNA leads to the emergence of an accurate genomic editing tool, the presence of an immutable PAM site significantly limits the areas of the genome in which editing can be performed. At the moment, more than 3.5 thousand of Cas proteins using different PAM sites have been identified in various bacteria with the help of bioinfomatic tools, but in practice less than ten PAM are used. To be able to use new proteins, it is necessary to obtain their characteristics. In particular the optimal physical and chemical conditions for enzyme, the structure of guiding RNA and PAM-sequence, characteristic for new protein. Currently, several programs have been created to determine PAM sequences for previously unexplored Cas protein analogues, but all of them prone to mistakes and require data confirmation from classical molecular biology. The purpose of this work was to create a new efficient algorithm and software for idetification of PAM sequences characteristic of any microorganism. To test the program, we used CRISPR bacterial cassettes, formed by Cas9 enzyme, as well as current homology search programs for the bacterial genomes. As a result of the study, a modular program was created that allows identifying the sequence of the PAM site based on the analysis of CRISPR cassettes with an efficiency not inferior to world analogues.
Только метаданные
The influence of chemical structure of nitrogen-containing heterocyclic compounds on the character of ion mobility spectra
(2019) Grishin, S. S.; Negru, K. I.; Baberkina, E. P.; Kovalenko, A. E.; Shaltaeva, Y. R.; Belyakov, V. V.; Golovin, A. V.; Gromov, E. A.; Matusko, M. A.; Шалтаева, Юлия Ринатовна; Беляков, Владимир Васильевич
© 2019 Published under licence by IOP Publishing Ltd. In this article, the trace amounts of nitrogen-containing compounds have been examined using ion-mobility spectrometry. Depending on the chemical structure of substances in the row of nitrogen-containing compounds ion-mobility spectra, different types of rules have been stated. The obtained ionograms have been analyzed to determine a probable ion-mobility value for certain functional groups.
Открытый доступ
Analysis of the ion mobility spectra of chloroacetophenone, tris(2-chloroethyl)amine, and methanethiol
(2024) Aleksandrova,D.A.; Melamed, T. B.; Baberkina, E. P.; Osinova, E. S.; Shaltaeva, Y. R.; Belyakov, V. V.; Шалтаева, Юлия Ринатовна; Беляков, Владимир Васильевич
Только метаданные
Exhaled breath mass spectrometry in heart failure diagnostics
(2019) Malinovskaya, L.; Bykova, A.; Chomakhidze, P.; Kopylov, F.; Patrikeev, L.; Vasilev, V.; Belyakov, V.; Golovin, A.; Pershenkov, V.; Malkin, E.; Gromov, E.; Ivanov, I.; Matusko, M.; Shaltaeva, Y.; Беляков, Владимир Васильевич; Малкин, Евгений Константинович; Иванов, Игорь Александрович; Шалтаева, Юлия Ринатовна
Copyright © 2019 Inderscience Enterprises Ltd.Heart failure (HF) affects almost all organs and systems, including general and local pulmonary metabolism, thus effecting on volatile organic compounds concentration in expired air. The aim of the present study is to evaluate the value of expired air analysis (proton mass spectrometry, PTR-MS) for the diagnosis of HF. The study population included 19 patients with stable chronic New York Heart Association (NYHA) functional classification class 2-3 and 16 sex and age matched controls without signs and symptoms of HF. Expired air analysis could provide facilities of early diagnosis and monitoring in HF patients. Most patients had ischemic aetiology of HF, and 31% of them had NYHA class 2 and 69% NYHA class 3 symptoms. Fasted expired air collected by special Tedlar bags was analysed by Compact PTR-MS. The composition of expired air was analysed by deviation of the content of certain substances against their concentration in neutral air. Analysis of samples from patients reveals 24 substances that differ in concentration from the neutral air. Six of them differ significantly in patients with and without HF. Namely, the concentrations of acetone, formaldehyde, propylene, acetic acid, xylene and benzoates were significantly elevated in HF patients (p > 0.05).
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Fast switching of the polarity of dual mode ion mobility spectrometer
(2019) Pershenkov, V.; Belyakov, V.; Shaltaeva, Y.; Malkin, E.; Golovin, A.; Ivanov, I.; Vasilyev, V.; Matusko, M.; Gromov, E.; Беляков, Владимир Васильевич; Шалтаева, Юлия Ринатовна; Малкин, Евгений Константинович; Иванов, Игорь Александрович
© 2019 IEEE.The ion mobility spectrometer with a fast switching of the polarity of the drift field is designed for alternate, incessant detection of positive and negative ions from nonradioactive active ionization source. It were also solved the problems of dielectric absorption on the collector and voltage stabilization on the protective ion grid.